Developmentof biodegradable polymer-calcium phosphate composite as a bone substitute material

磷酸钙（CaP）生物材料如羟基磷灰石（HA）、β-磷酸三钙（β-TCP）或其复合材料是常用的人工骨替代材料。近年来的研究表明，多孔结构的CaP材料具有良好的生物相容性，但多孔CaP材料的缺点是易碎易碎。我们开发了一种新型材料，该材料具有相互连接的孔，具有CaP纳米颗粒分散的可生物降解聚合物梁。本研究的目的是评估该材料作为骨替代材料。在大鼠颅骨中，观察到丰富的血管和细胞浸润到相互连接的毛孔中。在胫骨（大鼠研究）中，在材料孔内观察到新形成的骨。在这项研究中，PLLA和PCL似乎都具有生物相容性，没有任何炎症反应。此外，只有PLLA显示了细胞对孔隙的浸润。在cap分散的PLLA海绵内观察到新骨形成。这些结果表明，可生物降解聚合物- cap复合材料有望成为一种有效的骨替代材料

Calcium phosphate (CaP) biomaterials such as hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), or their composite are commonly used as artificial bone substitute materials. Recent researches indicated that the CaP materials with porous structure exhibited the excellent biocompatibility, however, the drawback of porous CaP materials is that they are extremely brittle and fragile. We developed the novel material with interconnected pores which had CaP nanoparticle-dispersed biodegradable polymer beams. The aim of this study was to evaluate this material as the bone substitute material. In calvaria (rat study), abundant blood vessels and cells infiltration into interconnected pores were observed. In the tibia (rat study), newly-formed bone was observed within the pore of the material. In this study, both PLLA and PCL seemed to be biocompatible, without any inflammatory response. Furthermore, only PLLA displayed the cell infiltration into the pores. New bone formation was observed inside the CaP-dispersed PLLA sponge. These results suggest that the biodegradable polymer-CaP composites is expected to be a potent bone substitute material