The association between serum antibody to the periodontal pathogen and chronic kidney disease

肾脏疾病被认为是一个全球健康问题；仅在日本，估计患有慢性肾脏疾病(CKD)的人数就有1330万，占总人口的12.9%。本研究的目的是调查血清中抗牙周病原体抗体与日本人慢性肾脏病之间的关系。数据来自215名年龄79岁的参与者。我们观察到，在控制了其他重要的健康特征后，血清抗牙龈假单胞菌抗体效价升高与肾功能下降之间存在显著的相关性。本研究的结果表明，在以社区为基础的日本老年人队列中，血清抗牙龈假单胞菌抗体效价升高与肾功能下降之间存在显著关联。未来的研究应该评估牙周治疗在降低慢性肾脏病发展或进展风险方面的作用。

Kidney disease is recognized as a global health problem; the estimated number of the people with chronic kidney disease (CKD) in Japan alone is 13.3 million, which represents 12.9% of the population. The aim of this study was to investigate the association between serum antibody to the periodontal pathogen and CKD in Japanese individuals. Data were available from 215 participants aged 79 yrs. We observed a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function, after controlling for other important health characteristics. The findings of the present study suggest that there is a significant association between elevated serum antibody titer to P. gingivalis and decreased kidney function in the community-based cohort of elderly Japanese. Future studies should evaluate the contribution of periodontal therapy in reducing the risk for the development or progression of CKD.