Development of procedures to prepare monoclonal plastic antibodies

在本研究中，我们旨在建立制备与目标肽相互作用的均匀聚合物配体的程序。我们首先确定了捕获目标肽蜂毒素的聚合物配体上功能基团的最小数量和组合。接下来，我们证明了通过亲和纯化程序可以分离出与蜂毒蛋白有强亲和关系的聚合物。最后，制备了嵌段共聚物库，确定了捕集蜂毒素的最佳序列。

In this research, we aimed to establish procedures to prepare uniform polymer ligands that interact with target peptide. We first identified the minimum number and combination of functional group on the polymer ligands to capture target peptide melittin. We next showed that polymers with strong affinity to melittin can be isolated by affinity purification procedure. As a final step, library of block copolymers were prepared and optimum sequence to capture melittin was assigned.