Manipulation of the growth potential and carcass composition of domestic animal species

寻找重复注射生长激素(GH)的替代品以提高生产效率并将屠体肥胖度降至最低仍然是动物研究的重要目标。这项应用利用了两种新的方法来实现这一目标：1.给新生儿注射生长激素释放肽，以在生长到成熟过程中印记增强的生长激素分泌模式和饲料转化效率；2.通过与VitB12结合开发这些肽的口服活性形式，以通过VitB12运输机制促进肠道吸收，并将其输送到接近成熟的动物的下丘脑/脑垂体轴。

Finding alternatives to repeated growth hormone(GH) injection to boost production efficiency and minimise carcass fatness remains an important target for animal research. This application exploits the two novel approaches to achieve this goal through: 1. the administration of the GH releasing peptides to the neonate to imprint an enhanced GH secretory pattern and feed conversion efficiency during growth to maturity and 2. the development of an orally active form of these peptides by conjugation with VitB12 to facilitate intestinal absorption through the VitB12 transport mechanism for delivery to the hypothalamic/pituitary axis of animals nearing maturity.