Elucidation of genetic mechanism of the reproductive isolation between mouse subspecies by using consomic strains.

生殖隔离是一种普遍存在于包括动植物在内的生物体中的现象。虽然植物中的一些遗传机制已经被阐明，但动物的遗传机制仍然不清楚。在这里，我们证明了小鼠亚种之间的生殖隔离不太可能是由一个或几个“物种形成基因”引起的，而是由于转录调控网络中的遗传不相容而导致的基因的广泛错误表达。

The reproductive isolation is a phenomena generally observed in organisms including plants and animals. Though some genetic mechanisms have been elucidated in plants, genetic mechanisms in animals are still obscure. Here we showed that the reproductive isolation between mouse subspecies is not likely caused by one or few “speciation genes” but by the extensive misexpression of genes due to the genetic incompatibility in transcriptional regulatory networks.