The functioning role of SNX protein in thyroid carcinogenesis

在正常甲状腺组织中，SNX 2表达于反映甲状腺细胞活性状态的柱状甲状腺滤泡细胞。大多数扁平的甲状腺细胞，这表明细胞处于非活性状态，没有显示出明显的SNX 2免疫染色。由活跃的甲状腺细胞表达的分拣蛋白在滤泡细胞中也表现出类似的分布。SNX 2在甲状腺细胞中的表达在大多数过度刺激的甲状腺疾病中特别显著，包括Graves病和功能性结节。在FRTL-5细胞中，当用促甲状腺激素刺激细胞时，细胞表达增加量的SNX 2和分拣蛋白。形态学分析显示细胞大小增加，与组织学结果一致。关于甲状腺癌，SNX 2对乳头状癌呈弥漫阳性。总之，SNX 2表达增加表明甲状腺细胞活跃，并可能反映甲状腺癌细胞内体运输水平增加。

In normal thyroid tissue, SNX2 was expressed in columnar thyroid follicular cells that reflect active state of thyrocytes. Most of the flattened thyrocytes, which indicates cells in inactive state, did not show apparent SNX2 immunostaining. Sortilin, which is expressed by active thyrocytes, also exhibited similar distribution in follicular cells. Expression of SNX2 in thyrocytes is particularly marked in most hyperstimulated thyroid disorders, including Graves disease and functioning nodules. In FRTL-5 cells, cells expressed increased amount of SNX2 and sortilin protein when cells were stimulated with thyroid stimulating hormone. Morphometric analysis revealed increased cell size that corresponds to histological findings. Regarding thyroid cancer, SNX2 was diffusely positive for papillary carcinoma. In sumary, increased SNX2 expression indicates active thyrocytes, and may reflect increased level of endosomal trafficking in thyroid cancer cells.