Creation of metal surface adhesive to soft tissue

为了使胶原蛋白均匀固定在钛表面而不发生胶原蛋白自组装，采用交替电沉积技术，阳极电流和阴极电流反复充电是最有效的方法。通过成纤维细胞培养评价钛固定胶原的软组织相容性。结果表明，细胞的初始粘附、扩张和增殖在表面没有受到抑制。另一方面，很难评估软组织与基体材料之间的结合强度。进一步的研究以获得可重复和可靠的sft组织相容性评价方案是必要的。

To immobilize collagen uniformly to titanium surface without self-assembly of collagen, electrodeposition technique with alternative current, repetition of anodic current and cathodic current charge, was the most effective. The soft tissue compatibility of titanium immobilized collagen was evaluated by cell culture of fibroblast. The results revealed that initial adhesion, expansion, and proliferation of cells were not inhibited on the surface. On the other hand, it was difficult to evaluate the bonding strength between soft tissue and substrate material. Further research to obtain reproducible and reliable evaluation of sft tissue compatibility protocol is necessary.