Common and distinct mechanisms for ARF6-mediated neuronal migration and cancer invasion

ADP核糖化因子是一种小的GTP酶，通过激活脂质修饰酶和募集各种相互作用的蛋白如FIP3/4和JIP3/4来调节膜运输和肌动蛋白重塑。最近的证据表明，ARF6通路在肿瘤侵袭和转移等细胞运动中具有重要的功能。这项研究的目的是测试ARF6通路是否可能参与皮质层形成过程中的神经元迁移。我们发现，I型磷脂酰肌醇4-磷酸5-激酶r(PIP5KIr)是一种磷脂酰肌醇4，5-二磷酸(PtdIns(4，5)P2)合成酶，其功能是Arf6的下游效应因子，可能是通过将黏附成分募集到质膜来实现神经元迁移的。

ADP ribosylation factor is a small GTPase that regulate membrane traffic and actin remodeling through the activation of lipid modifying enzymes and recruitment of various interacting proteins such as FIP3/4 and JIP3/4. Recent evidence indicates the functional importance of ARF6 pathways in cell motility such as cancer invasion and metastasis. The aim of this study is to test the possibility whether the ARF6 pathway may be involved in neuronal migration during cortical layer formation. We found that type I phosphatidylinositol 4-phosphate 5-kinase r (PIP5KIr), a phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)-synthesizing enzyme that functions as a downstream effector of Arf6, is required for neuronal migration possibly through recruitment of adhesion components to the plasma membrane.