Discovery of intramitochondrial lysosome

在这项研究中，我们对线粒体内溶酶体的诱导机制有了一些重要的发现。首先，BNIP3和Nix这两种线粒体外膜蛋白在线粒体内溶酶体的诱导中起着关键作用。Mieap、BNIP3和Nix在线粒体外膜上的相互作用导致线粒体双膜开孔。令人惊讶的是，这与细胞死亡完全无关。其次，14-3-3Gamma与Mieap相互作用并移位到线粒体中。线粒体内14-3-3-γ在清除氧化的线粒体蛋白中起着关键作用。这些结果表明，线粒体双膜上一个孔的打开和一个接头蛋白在线粒体内溶酶体的机制中是非常重要的。

In this study, we obtained several important findings on the mechanism for induction of the intramitochondrial lysosome. First, BNIP3 and NIX, two mitochondrial outer membrane proteins, play a pivotal role in induction of the intramitochondrial lysosome. The interaction of Mieap, BNIP3 and NIX at mitochondrial outer membrane induces the opening of a pore in the mitochondrial double membrane. Surprisingly, this is completely unrelated to cell death. Second, 14-3-3gamma interacts with Mieap and is translocated into mitochondria. Intramitochondrial 14-3-3gamma plays a critical role in the elimination of oxidized mitochondrial proteins. These results suggest that the opening of a pore in the mitochondrial double membrane and an adaptor protein are very substantial in the mechanism for the intramitochondrial lysosome.