Relation analysis between odorant receptors and specific behaviors in mammls

我们发现了一系列气味剂（恐惧气味），它们对诱导小鼠的先天冻结行为具有极强的活性。我们明确了化学结构的规则，这是诱发先天恐惧情绪所不可缺少的。我们克隆了大约1000个气味受体，代表了小鼠基因组中几乎所有的小鼠气味受体，建立了一个表达筛选系统，并分析了恐惧气味与气味受体的结合特异性。因此，我们澄清了一种可能性，即除了气味受体的特异性外，气味的化学结构对诱导恐惧情绪也很重要。我们发现了一些动物物种对恐惧气味有特别的反应。

We identified a series of odorants (fear odors) which has extremely strong activity to induce innate freezing behaviors in mice. We clarified rules of chemical structures ,which is indispensable to induce innate fear emotions. We cloned about 1000 odorant receptors, representing almost all of mouse odorant receptors in the mouse genome, to develop an expression screening system , and analyzed the binding specificity of fear odors and odorant receptors. As a result, we clarified the possibility that, in addition to the specificities of odorant receptors, chemical structures of odorants are also important to induce fear emotions. We identified a number of animal species that specifically respond to fear odors.