The study of the coupling mechanisms between the voltage sensor and the enzymatic activity of voltage-sensing phosphatase, VSP

电压敏感磷酸酶（Voltage-sensing phosphatase，VSP）由电压敏感元件和磷酸酶结构域组成。在本研究中，我们研究了VSP的电压传感器如何调节其磷酸酶活性。我们的研究结果表明，不仅完全激活，而且部分激活的电压传感器触发磷酸酶活性。这意味着通过电压传感器调节磷酸酶结构域的机制与传统电压门控离子通道中通过电压传感器调节离子孔活性的机制不一致。我们的研究为电压传感器的性质提供了新的见解。

Voltage-sensing phosphatase, VSP consist of the voltage sensor and the phosphatase domain. In this study, we have investigated how the voltage sensor of VSP regulates its phoshpatase activities. Our results indicate that not only full activation but also partial activation of the voltage sensor triggers the phosphatase activity. This means that the mechanisms to regulate the phosphatase domain by the voltage sensor is not consistent with those to regulate the activity of ionic pore by the voltage sensor in conventional voltage-gated ion channels. Our research provided new insight into thenature of voltage sensors.