Effect of exercise training on formation of brite adipocytes within white adipose tissue

越来越多的证据表明，暴露在儿茶酚胺中会导致白色脂肪组织中的棕色脂肪细胞，即白脂肪细胞。人们普遍认为，持续的体育锻炼会使白色脂肪细胞暴露于儿茶酚胺中，这表明体育锻炼可能会刺激白色脂肪组织中白脂肪细胞的形成。结果表明，持续跑步运动可促进大鼠皮下白色脂肪组织中白脂肪细胞的形成。在这种情况下，ppar的功能亢进和/或其与PRDM16的相互作用在这一机制中发挥了关键作用。

The growing body of evidences has suggested that exposure of catecholamines give rise to brown-in-white adipocytes, which are referred to as brite adipocytes, within white adipose tissues. It has been widely accepted that continuous physical exercise exposes white adipocytes with catecholamines, suggesting the possibility that physical exercise would be expected to stimulating the formation of brite adipocytes in white adipose tissues.Our result indicated that continuous running exercise promotes formation of brite adipocytes in rat subcutaneous white adipose tissue. Under this condition, hyperfunction of PPAR and/or its interaction with PRDM16 was shown to play a critical role in this mechanism.