Association of genetic polymorphisms and lifestyle factors with postprandial autonomic nervous response and gastric motility

自主神经系统功能低下和胃运动功能低下分别与心血管疾病、代谢性疾病和功能性胃病密切相关。本研究通过心率变异性分析和胃电检查，探讨了Ghrelin、生长激素促分泌素受体、缩胆囊素受体和G-Protenβ3亚单位等基因多态性和生活方式因素(体力活动和饮食习惯)与健康青年人群餐后自主神经反应和胃动力的关系。目前的研究表明，体重指数、血压以及Ghrelin和GNB3基因的多态与餐后胃动力独立相关。此外，本研究还调查了摄入咖啡对年轻健康受试者胃动力和自主神经活动的影响。结果表明，咖啡的摄入增强了胃动力和自主神经活动，这些影响在不习惯喝咖啡和习惯喝咖啡的人中是不同的。

Hypofunction of autonomic nervous system and gastric motility is closely related to cardiovascular and metabolic diseases and functional gastric disorder, respectively. This study investigated the association of genetic polymorphisms (ghrelin, growth hormone secretagogue receptor, cholecystokinin receptor, and G-proten β3 subunit(GNB3)) and lifestyle factors (physical activity and dietary habit) with postprandial autonomic nervous response and gastric motility using heart rate variability analysis and electrogastrography in young healthy subjects. The present study showed that body mass index, blood pressure, and polymorphisms in ghrelin and GNB3 genes were independently associated with postprandial gastric motility. In addition, present study investigated the effects of coffee intake on gastric motility and autonomic nervous activity in young healthy subjects. Results suggest that coffee intake enhances gastric motility and autonomic nervous activity, and these effects are different between non-habitual and habitual coffee drinkers.