Effects of maternal nutrition for essential metals on placental leptin expression

在妊娠小鼠和人胎盘绒毛膜癌细胞系JEG-3中研究了母体必需金属缺乏和过量对胎盘瘦素表达的影响。必需金属缺乏小鼠血浆瘦素和瘦素受体表达水平降低，而过量小鼠血浆瘦素受体表达水平升高。这些结果提示胎盘源性瘦素及其受体的表达可能受母体对胎儿发育必需金属的营养控制。

Effects of maternal deficiency and overload of essential metals on placental leptin expression were studied in pregnant mice and human placental choriocarcinoma cell line JEG-3. The levels of plasma leptin and leptin receptor expression were decreased in essential metals deficient mice and increased in them overloaded mice. These results suggest that placenta-derived leptin and its receptor expression may be controlled by maternal nutrition of essential metals for fetal development.