Clinical application of TGF-beta signal in chronic hepatitis B

在我们最近的研究中，通过抗病毒治疗在早期清除HBV可以恢复肝细胞tgf - β信号从纤维癌变到肿瘤抑制。此外，低pSmad3C和高pSmad3L阳性可显著预测人类HCC的发展。我们的结论是，pSmad3L和pSmad3C可以作为一种有用的标志物，来确定你是否可以通过抗病毒治疗来防御病毒相关HCC的发展。使用个体磷酸化- smad3标记物，临床医生可能能够对HBV感染患者实现更有效的化学预防和个体化治疗。

In our recent studies, HBV clearance at an early stage by anti viral therapy restored hepatocytic TGF-beta signaling from fibro carcinogenesis toward the tumor suppression. Moreover, low pSmad3C and high pSmad3L positivity were significantly predictive of human HCC development. We conclude that pSmad3L and pSmad3C can serve as a useful markers determining whether you can defend development of viral related HCC by antiviral therapy. Using an individua s phospho-Smad3 markers, clinicians may be able to achieve more effective chemoprevention and individualized therapy for HBV infected patients.