Mechanism and control of inflammation and organ failure in crush syndrome.

挤压伤患者常出现全身炎症反应综合征，并陷入多器官功能衰竭，但其机制尚不清楚。(1)在挤压伤大鼠模型上，应用抗RAGE抗体可减轻炎症反应，提高存活率。(2)SIRS患者血清sRAGE较正常明显升高。可溶性RAGE与血清HMGB1或急性DIC评分相关。RAGE的表达反映了血清可溶性RAGE。在SIRS患者中，RAGE的表达可能增加。这些结果表明，阻断RAGE如抗RAGE抗体可能成为治疗挤压综合征或SIRS的一种有前途的新疗法。

Patients with crush injury often present systemic inflammatory response syndrome and fall into multiple organ failure, but the mechanism is still unclear. We focused on RAGE.(1)In Rat model of crush injury, administration of anti-RAGE antibody reduced inflammatory reaction and improved survival. (2)Patient with SIRS, serum soluble RAGE increased significantly than normal. Soluble RAGE was related to serum HMGB1 or acute DIC score. Expression of RAGE reflect to serum soluble RAGE. In patients with SIRS, RAGE expression may be increased.These results indicate blocking of RAGE such as anti-RAGE antibody may become a promising novel therapy against crush syndrome or SIRS.