Development of gene therapy for oral cancer mediated by Naked DNA of molecule processing E-cadherin

本研究表明，口腔癌细胞转移的纤溶酶抑制剂alpha2-antiplasmin （alpha2-AP）基因在体内肿瘤形成过程中明显受到抑制，形成的肿瘤中E-cadherin的表达增加。结果表明，诱导α 2- ap蛋白不仅通过增加蛋白水解活性，而且通过增加细胞迁移和增殖抑制肿瘤的侵袭和转移。因此，通过诱导α 2- ap治疗口腔癌的新基因疗法有望发展。

This study showed that oral cancer cells transferred gene of alpha2-antiplasmin (alpha2-AP) which is plasmin inhibitor were remarkably suppressed in vivo tumor formation and expression of E-cadherin increased in the formed tumor. The results suggest that inducing of alpha2-AP protein suppresses tumor invasion and metastasis by increasing not only proteolytic activity but also cell migration and proliferation. Therefor, it is expected the development of novel gene therapy by inducing of alpha2-AP for oral cancer.