Elucidation of pharmacological action of docosahexaenoic acid on the function of vascular smooth muscle cells exposed to pulsatile pressure

本文研究了压力应激对血管平滑肌细胞（VSMCs）功能的影响以及二十二碳六烯酸（DHA）对VSMCs功能的影响。 采用自行设计的脉动压力负荷装置，模拟收缩期高血压的压力负荷作用于血管平滑肌细胞。 压力应激降低了白细胞介素1 β诱导的环氧合酶2（考克斯-2）的表达，促进了VSMCs的肥大。 压力降低细胞外信号调节激酶的激活可能导致考克斯-2的减少。 二十二碳六烯酸DHA可防止考克斯-2减少和肥大。

The effect of pressure stress on vascular smooth muscle cells (VSMCs) function and the effect of docosahexaenoic acid (DHA) on the function were investigated. The pressure stress which can simulate systolic hypertension was exposed to VSMCs by using an originally designed pulsatile pressure-loading apparatus. The pressure stress reduced interleukin-1beta-induced cyclooxygenase-2 (COX-2) expression and stimulated VSMCs hypertrophy. Reduced extracellular signal-regurated kinase activation by the pressure may cause the COX-2 reduction. Docosahexaenoic acid DHA prevented the COX-2 reduction and the hypertrophy.