マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成

所提出的研究目标顺利完成。成功制备了姜黄素-聚酯纳米颗粒的微流控装置。用共聚焦荧光显微镜捕捉了微流控器件内纳米颗粒的合成过程。利用优化后的器件对合成的cu - pe NPs进行了动态光散射表征，得到了目标粒径分布。平均粒径小于100 nm，多分散性指数小于0.2，表明所制备的微流控装置为cu - pe NPs的形成提供了可控的环境。这些结果证实了微流控装置是开发用于药物递送的新型聚酯纳米颗粒的绝佳工具。除了对合成的cu - pe NPs进行物理表征外，还利用紫外可见光谱对其在溶液中的降解动力学进行了研究。结果表明，这些Cur-PE NPs在数天内是稳定的。此外，包封的姜黄素分子在水环境中显著溶解和稳定。该研究表明，微流体装置是开发新型聚酯纳米颗粒药物递送的独特平台。本研究结果表明，微流控合成的curc - pe NP具有作为姜黄素药物载体的潜力。这些结果已在国际研讨会和会议上发表，目前正在准备在国际同行评审期刊上发表一份手稿。

The proposed research goals are completed smoothly as expected. Microfluidic devices for curcumin-polyester nanoparticle (Cur-PE-NPs) synthesis has been fabricated successfully. The synthesis of nanoparticle inside microfluidics devices was captured with confocal fluorescence microscope. The synthesized Cur-PE NPs were characterized with dynamic light scattering and target particle size distributions were achieved with the optimized devices. The average particle sizes are less than 100 nm with a polydispersity index of less than 0.2, which indicate the fabricated microfluidic devices provide a controlled environment for the formation of Cur-PE NPs. These results confirm that microfluidic devices are excellent tools in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur-PE NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur-PE NPs are stable for days. Furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. This research has demonstrated that microfluidic devices are unique platforms in the development of novel polyester nanoparticles for drug delivery. Our results suggest that the microfluidic synthesized Cur-PE NP have potential as drug carrier for curcumin. These results have been presented in international symposium and conference and a manuscript is currently in preparation for publication in an international peer-reviewed journal.