Chiral Alkyllithium Bases

衍生自市售烷基锂试剂和手性添加剂（助剂）的手性烷基锂碱（主要为二胺形式）是通过去质子化反应传递立体化学信息的重要试剂。在这一研究领域，催化变体的发现仍然是一个重大挑战。在该项目的前一段时间内，我们能够从结构上表征这类试剂的一些重要代表，并阐明了系统的结构-反应性关系。从这些研究中可以看出，这些知识对于更好地理解这些反应的机理也是至关重要的。在该项目的过程中，我们在烷基锂碱领域的成就获得了许多国家和国际奖项，并在著名期刊上发表。本论文的研究目标将集中于研究新型的去质子化试剂和高电位活化概念，这是迄今为止发展很少的。在这种情况下，主要的注意力将转向合成手性结构单元用作手性催化剂。研究固体结构的方法和用于溶液中结构解析的新型NMR方法以及由量子化学计算支持的立体化学研究的结合，将为正在进行的过程提供详细的见解。

Chiral alkyllithium bases derived from commercially available alkyllithium reagents and chiral additives (auxiliaries), mostly in the form of diamines, are important reagents for transferring stereochemical information via deprotonation reactions. In this area of research, the discovery of catalytic variants still remains a major challenge. Within the previous duration of the project we were able to structurally characterize some important representatives of such kinds of reagents and elucidated systematic structure-reactivity relationships. It follows from these studies that this knowledge is also crucial for a better mechanistic understanding of these reactions. In the course of the project our achievements in the field of alkyllithium bases were honored by lots of national and international awards and published in prestigious journals. The research objective will focus on investigating novel deprotonation reagents and activation concepts of high potential, which are only little developed so far. In this context, major attention will be turned towards the synthesis of chiral building blocks for a use as chiral catalysts. The combination of methods for investigating solid structures and novel NMR methods for structural elucidation in solution as well as stereochemical studies, supported by quantum chemical calculations, will provide detailed insights into the ongoing processes.