Comparative mitochondrial genomics of Bilateria

线粒体基因组为双边动物的系统发育分析提供了一套强大的数据。除了纯序列数据外，许多附加信息在系统发育背景下是有用的，例如基因重排，基因的重复或丢失，trna和rnas的二级结构，以及线粒体遗传密码的变化。在之前的项目中，我们可以在没有完整的有丝分裂基因组数据的情况下填补一些双边类群的重要空白（如Onychophora， Tardigrada, Sipuncula, Myzostomida, Nemertea）。但仍有一些高级类群没有线粒体全基因组序列记录，如翼branchia、Acoelomorpha、Gnathostomulida、Nematomorpha等。在其他类群中发现线粒体基因顺序存在较大差异，因此需要更多的数据来更好地了解这些类群的基因组重排模式。这些动物包括：外腹纲、内腹纲、被膜纲、非寄生白蛉。这项研究的一个主要目的是提供一个详细的情景线粒体基因组进化的双边动物。

Mitochondrial genomes provide a powerful set of data for phylogenetic analyses among bilaterian animals. Besides pure sequence data a multitude of additional information is useful in phylogenetic contexts, e.g. gene rearrangements, duplication or loss of genes, secondary structures of tRNAs and rRNAs, as well as changes in the mitochondrial genetic code. In the preceding project we could close some important gaps of bilaterian taxa without complete mitogenomic data (e.g. Onychophora, Tardigrada, Sipuncula, Myzostomida, Nemertea). But there are still high-ranking taxa without sequence records of complete mitochondrial genomes, e.g. Pterobranchia, Acoelomorpha, Gnathostomulida, Nematomorpha. In other taxa a great variation of mitochondrial gene order is found, so more data is in need for a better understanding of the mode of genome rearrangements in these taxa. These include e.g. Ectoprocta, Entoprocta, Tunicata, non-parasitic Platyhelminthes. One main objective of the study is to provide a detailed scenario of mitochondrial genome evolution among Bilateria.