Subcortical processing of visual fear stimuli in the common marmoset

我已经完成了我的JSPS fellow，非常感谢JSPS给了我这么好的机会和资金来支持我的研究。在我的研究中，我已经取得了几个重要的里程碑。首先，我记录了头部受限的狨猴在观看恐惧和非恐惧图片时的眼球运动。很明显，他们花更多的时间看那些可怕的照片。我还成功地在狨猴身上测试了几种不同的3D打印植入物。此外，我用扫视任务训练狨猴，目前我正在写一篇关于结果的手稿。作为附带成果，我还成功地对狨猴皮层进行了微刺激，并确定了与扫视相关的一个重要大脑区域。我已经完成了数据采集，即将开始写稿件。成功建立了狨猴脑显微注射方法，成功追踪上丘。这是一个非常重要的结果。正如去年所述，我还对同一只狨猴进行了两次注射，一次在上丘逆行，一次在杏仁核逆行，以探索这两个大脑区域之间的联系。我目前正在测试几种AAV病毒，以便为未来的光遗传学实验提供良好的表达。在JSPS的资助下，我还参加了一些本地和国际会议来展示我的工作，并得到了其他研究人员的反馈。总的来说，我相信我已经达到了我之前设定的几个目标，我想继续我对先天恐惧的研究。

I have finished my JSPS fellow and am grateful that JSPS gave me such a good opportunity with funding to support my research. I have achieved several important milestones regarding my research. First, I have recorded eye movements from head-restrained marmosets while they were viewing fearful and non-fearful pictures. It was clear that they spent more time looking at the fearful pictures. I have also successfully tested several different 3D printed implants on the marmosets. Furthermore, I have trained the marmosets with saccade tasks and I am currently writing a manuscript on the results. As a side product, I have also successfully performed microstimulation in marmoset cortex and identified an important brain area related to saccade. I have finished the data acquisition and will start to write the manuscript soon. I also successfully established method for brain microinjection on marmosets and successfully traced the superior colliculus. This is very important result. As what stated last year, I have also performed double injection, one anterograde in the superior colliculus and one retrograde in the amygdala in the same marmoset to exploring the connection between the two brain areas. I am currently testing several types of AAV virus to have good expression for future optogenetic experiments. With the grant provided by JSPS, I have also participated several local and international conferences to present my work and got feedbacks from other researchers. Overall, I believe I have reached several goals I set before and I would like to continue my research about innate fear.