コモンマーモセットの前頭葉ー頭頂葉系の障害が半側空間無視を誘発する神経機構

额顶叶系统疾病导致普通狨猴半侧空间忽视的神经机制

基本信息

批准号：
16F14766
负责人：
伊佐正
金额：
$ 0.77万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2016
资助国家：
日本
起止时间：
2016-04-22 至 2017-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16F14766/
关键词：
eye movement attention marmoset saccade free viewing

项目摘要

The main focus of the last year was on building up the laboratory for eye tracking research in marmosets. We developed a dual way to fix the marmoset's head: the squeeze helmet made from moldable plastic pressing the head from two sides and the surgically implantable head-post.Initially, the main focus has been on free-viewing experiments, where the head-squeezed marmosets observed naturalistic stimuli. In a pilot project, we tested 5 controls and 4 poly IC marmosets from the National Institute of Radiological Sciences showing some behavioural abnormalities similar to human schizophrenia. Currently, the obtained data is being analysed and we hope to produce a publication from the results.Lately, the focus has shifted to the fixation training, which allows a more precise calibration of the gaze data and conditioning of the behaviour. 4 marmosets are trained using the head-squeeze now and 1 marmoset has been implanted with the head-post and his training has also begun. More than 30 different software scripts have been written to present marmosets with various visual stimuli. Also stand-alone computer programs for gaze calibration and online visualisation of the gaze data has been written. 2 marmosets have already learned to fixate to the centrally presented stimuli. Physiological and optogenetic manipulations will follow as soon as enough marmosets have been trained in fixation and saccade tasks. Anatomical research of the oculomotor pathways in the marmosets has also been ongoing and results will be presented during the 40th annual meeting of Japan Neuroscience Society.

去年的主要重点是建立在摩尔马人的眼睛跟踪研究的实验室。我们开发了一种双重方法来固定马尔莫斯特的头部：由可塑性塑料制成的挤压头盔从两侧按下头部和手术可植入的头部。从目的中，主要的重点一直是免费观看的实验，在那里，头拼图的Marmosets观察到了自然主义的刺激。在一个试点项目中，我们测试了美国国家放射科学研究所的5个对照和4个Poly IC Marmoset，显示出与人类精神分裂症相似的某些行为异常。目前，正在分析获得的数据，我们希望从结果中产生出版物。期，重点已转移到固定培训上，这可以更精确地校准目光数据和行为条件。现在使用头侧训练了4匹摩尔果会，并且已经植入了1个果棒，并开始培训他的训练。已经编写了30多个不同的软件脚本，以呈现各种视觉刺激的marmosets。还编写了目光数据的凝视校准和在线可视化的独立计算机程序。 2个摩尔果已经学会了固定在中央呈现的刺激上。一旦对固定和扫视任务进行了足够的摩尔奶酪训练，就会紧随生理和光遗传学的操作。关于马尔莫斯特人的动眼途径的解剖学研究也一直在进行，结果将在日本神经科学学会的第40届年度会议期间提出。