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コモンマーモセットの前頭葉ー頭頂葉系の障害が半側空間無視を誘発する神経機構

额顶叶系统疾病导致普通狨猴半侧空间忽视的神经机制

基本信息

批准号：
16F14766
负责人：
伊佐正
金额：
$ 0.77万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2016
资助国家：
日本
起止时间：
2016-04-22 至 2017-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16F14766/
关键词：
eye movement attention marmoset saccade free viewing

项目摘要

The main focus of the last year was on building up the laboratory for eye tracking research in marmosets. We developed a dual way to fix the marmoset's head: the squeeze helmet made from moldable plastic pressing the head from two sides and the surgically implantable head-post.Initially, the main focus has been on free-viewing experiments, where the head-squeezed marmosets observed naturalistic stimuli. In a pilot project, we tested 5 controls and 4 poly IC marmosets from the National Institute of Radiological Sciences showing some behavioural abnormalities similar to human schizophrenia. Currently, the obtained data is being analysed and we hope to produce a publication from the results.Lately, the focus has shifted to the fixation training, which allows a more precise calibration of the gaze data and conditioning of the behaviour. 4 marmosets are trained using the head-squeeze now and 1 marmoset has been implanted with the head-post and his training has also begun. More than 30 different software scripts have been written to present marmosets with various visual stimuli. Also stand-alone computer programs for gaze calibration and online visualisation of the gaze data has been written. 2 marmosets have already learned to fixate to the centrally presented stimuli. Physiological and optogenetic manipulations will follow as soon as enough marmosets have been trained in fixation and saccade tasks. Anatomical research of the oculomotor pathways in the marmosets has also been ongoing and results will be presented during the 40th annual meeting of Japan Neuroscience Society.

去年的主要重点是建立实验室，用于对绒猴进行眼动跟踪研究。我们开发了一种双重的方法来固定绒猴的头部：由可模压塑料制成的挤压头盔从两侧挤压头部，以及手术植入的头柱。最初，主要的焦点是自由观察实验，在那里头部挤压绒猴观察自然主义刺激。在一个试点项目中，我们测试了来自美国国家放射科学研究所的5只对照猴和4只多IC狨猴，显示出一些与人类精神分裂症类似的行为异常。目前，我们正在对获得的数据进行分析，并希望通过分析结果发表文章。最近，研究重点转移到了注视训练上，这使得注视数据的校准和行为的调节更加精确。4只绒猴现在使用头部挤压进行训练，1只绒猴已经植入头柱，并且他的训练也已经开始。已经编写了30多种不同的软件脚本，为绒猴提供各种视觉刺激。此外，独立的计算机程序的凝视校准和在线可视化的凝视数据已被写入。2.绒猴已经学会了注视中央呈现的刺激。一旦足够多的绒猴接受了注视和扫视任务的训练，生理学和光遗传学操作就会随之而来。对绒猴眼神经通路的解剖学研究也在进行中，研究结果将在日本神经科学学会第40届年会上公布。