SFB 638: Dynamics of Macromolecular Complexes in Biosynthetic Transport

合作研究中心旨在分析导致大分子折叠、细胞内运输和特定定位的复杂多蛋白质系统的动力学。动力学是一)在细胞生物学水平上描述蛋白质/蛋白质、蛋白质/核酸和蛋白质脂相互作用形成的高级复合体，这些相互作用是该计划所有项目的核心，以及ii)关于这些单个复合体内变化的动力学，例如它们的构象变化、聚合或亚复合体的形成。在一些项目中，将用生化/生物物理方法对这方面进行分析。通过将病毒学和分子细胞生物学项目结合在一个共同的倡议中，可以具体实现主题的补充和延伸。在这些生物研究领域中提出的类似概念和问题将产生协同效应。

The Collaborative Research Centre aims at analysing the dynamics of complex multiprotein systems that cause folding, intracellular transport and specific localisation of macromolecules. Dynamics are of interest i) at a cell biological level to describe the formation of higher complexes by protein/protein, protein/nucleic acid, and protein lipid interactions central for all projects of the program, and ii) with respect to the kinetics of changes within such individual complexes, e.g. their conformational change, polymerisation or formation of subcomplexes. This aspect will be analysed by biochemical/biophysical methods in some of the projects. A complementation and extension of topics is reached specifically by combining virological and molecular cell biological projects within a mutual initiative. Synergetic effects will arise from similar concepts and questions asked in these fields of biological research.