Total synthesis of novel neurotrophic agents

天然产物合成是合成化学家最具挑战性的课题之一。在自然界中，数百万年来已经创造了一系列取之不尽的功能分子实体，经过高效的进化筛选，而非常目标特异性的化合物出现了。由于其独特的药理活性和在生物系统中的特定相互作用，天然产物非常适合作为药物发现的先导结构。由于自然资源通常是稀缺的，并且在药物开发中需要产生结构类似物，因此合成方法在利用大自然的指导手册开发新药方面发挥着关键作用。因此，实际合成的发展是优化先导化合物结构以及理解潜在药物的复杂作用模式和构效关系的有价值的工具。

Natural product synthesis represents one of the most challenging subjects for synthetic chemists. In nature, an inexhaustible array of functional molecular entities has been created over millions of years, being subjected to highly efficient evolutionary screenings whereas extraordinarily target specific compounds arose. Due to their unique pharmacological activity and specific interaction in biological systems, natural products are ideally suited as lead structures for drug discovery. Since natural resources are often scarce and in drug development the generation of structural analogues is desired, synthetic approaches play a key role in availing of nature s instruction manual towards novel Pharmaceuticals. Therefore the development of practical syntheses serves as a valuable tool for the optimization of lead structures as well as the understanding of complex modes of action and structure-activity-relationships of potential drugs.