Behavioural strategies and neurophysiological concepts for rehabilitation of impaired dexterity in subcortical stroke

该项目旨在发展行为策略和神经生理学概念，以改善皮质下中风后患手的灵活性。第一项研究应该在行为和神经水平上评估皮层下卒中后抓握和举起物体时快速感觉运动学习和联想学习的缺陷。第二项研究应调查替代行为策略对改善中风后灵巧性的影响，这些策略包括（i）将物体特异性体感信息从健侧转移到患侧，（ii）基于任意感觉线索与患侧关联学习相关机械物体特性。初级运动皮层（M1）和背侧前运动皮层（PMd）分别在快速感觉运动和联想学习中所起的不同作用，应在神经水平上通过fMRI进行研究。根据脑卒中后半球间竞争的概念，重复经颅磁刺激（rTMS）的治疗效果应在第三项研究中进行：1应测试（a）抑制（1Hz rTMS）对侧M1或（B）易化（10Hz rTMS）对患手抓握和举起物体时快速感觉运动学习的影响。

The project aims to develop behavioural strategies and neurophysiological concepts toimprove dexterity at the affected hand after subcortical stroke. A first study should assess thedeficit of both rapid sensorimotor learning and associative learning when grasping und liftingobjects after subcortical stroke both at a behavioural and neural level. A second study shouldinvestigate the impact of alternative behavioural strategies to improve dexterity after stroke.Such strategies include (i) transfer of object-specific somatosensory information from theunaffected to the affected hand and (ii) associative learning of the relevant mechanical objectproperties with the affected hand based on arbitrary sensory cues. The differential rolesplayed by the primary motor (M1) and dorsal premotor (PMd) cortices for rapid sensorimotorand associative learning, respectively, should be studied on a neural level by fMRI. Based onthe concept of interhemispheric rivalry following stroke, the therapeutic effects of repetitivetranscranial magnetic stimulation (rTMS) should be investigated in a third study:1 the effectsof (a) inhibition (1Hz rTMS) of contralesional M1 or (b) facilitation (10Hz rTMS) of ipsilesional M1 on rapid sensorimotor learning when grasping and lifting objects with the affected Hand should be tested.