Priority Program 1316: administration and conferences

优先项目“细菌病原体的宿主适应代谢”研究细菌病原体对宿主细胞和生物体的代谢适应。该项目已经形成了一个跨学科的研究小组网络，具有感染生物学、生物分析和生物信息学方面的专业知识，并允许解决宿主和病原体之间复杂的代谢相互关系。由于对方法和仪器的高要求，以前很少进行这样的分析。参与小组调查具有细胞内或细胞外生活方式的临床重要细菌病原体，食源性病原体或植物病原体。在这些方法中，同位素技术起着核心作用。由于该技术灵敏度的最新进展，现在可以在感染期间以高分辨率分析代谢通量。建立了一个“生物分析”平台，为大量参与小组提供所需的同位素分析技术。同样具有中心重要性的是用于代谢通量建模的“生物信息学”平台，用于生成用于分析代谢和同位素方法数据的生物信息学工具以及用于生成数据库的平台。2009年4月，重点项目举办了首届“代谢与毒力”国际会议。申请的行政项目应支持协调，包括行政助理、差旅费和行政支助的综合基金。第二阶段从2011年到2014年，计划召开两次科学会议，并申请资助。国际会议“代谢与毒性2”应于2013年举行，并应扩大国际合作和优先计划的可见度。2014年，计划举行一次全国总结研讨会，所有优先项目成员和其他主讲人都将参加。

The priority program 'Host-adapted metabolism of bacterial pathogens' investigates the metabolic adaptation of bacterial pathogens to host cells and organisms. The program has led to an interdisciplinary network of research groups with expertise in infection biology, bioanalytics and bioinformatics and allowed to address the complex metabolic interrelation between host and pathogen. Such analyses could previously rarely be performed due to the high demands in methodology and instrumentation. The participating groups investigate clinically important bacterial pathogens with an intracellular or extracellular lifestyle, food-borne pathogens or pathogens of plants. The isotopolog technique has a central role in many of these approaches. Due to recent advances in the sensitivity of this technique, it is now possible to analyze metabolic fluxes with high resolution during infection. A platform 'bioanalytics' was established that offers isotopolog profiling techniques demanded by a large number of participating groups. Of equally central importance is the platform 'bioinformatics' for the modelling of metabolic fluxes, for the generation of bioinformatics tools for analyses of data from metabolom and isotopolom approaches and for database generation. In April 2009, the priority program held the first international conference ‘Metabolism Meets Virulence’. The administrative project applied for should support the coordination, including an administrative assistant, travel and lumps fund for administrative support. Within the second phase from 2011 to 2014, two scientific conferences are planned, for which funding is requested. The international conference Metabolism Meets Virulence 2' should take place in 2013 and should extend international collaboration and visibility of the priority program. In 2014, a national summary symposium is planned with participation of all priority program members and additional keynote speakers.