An experimental study on the antigenicity of inorganic ceramics using as biomaterials.

在免疫后2周和4周，用磷酸三钙陶瓷免疫的小鼠中观察到显著的足垫肿胀。在交叉设计中证明了抗原特异性。反应的时间进程表明迟发型超敏反应起了重要作用。另一方面，给药磷灰石-硅灰石玻璃陶瓷后，小鼠死亡。死亡是由陶瓷粉末本身诱导的，而不是由粉末的上清液诱导的。显著的足垫肿胀表明存在对磷灰石-硅灰石的迟发型超敏反应。细胞色素c在硅胶上的吸附符合Langumuir吸附等温式。此外，二氧化硅诱导细胞色素c的电子转移。

Significant footpad swelling was observed in mice immunized with tricalcium phosphate ceramic at 2 and 4 weeks after immunization. Antigenic specificity was demonstrated in cross-over design. Time course of the reaction suggest that delayed-type hypersensitivity played an important role. On the other hand, mice were died after administration of apatite-wollastonite glass ceramic. The death was induced by the ceramic powder itself, and was not induced by the supernatant of the powder. Significant footpad swelling showed the presence of delayed-type hypersensitivity against apatite-wallostonite. The adsorption behavior of cytochrome c on silica obeys the Langumuir adsorption irotherm. Furthermore, silica induced electron transfer of cytochrome c.