Defining how gut bacteria regulate metabolism: a role for gut serotonin

该项目旨在了解肠道中产生血清素的细胞如何与肠道细菌（微生物组）相互作用，使用培养细胞和活的无菌和转基因小鼠的组合。该项目期望产生关于细胞相互作用的新知识，这些相互作用是重要生理途径的基础，如血糖和脂肪储存的控制。该项目的预期结果是确定肠道细菌如何与产生血清素的细胞交流以调节代谢，以及饮食是否通过肠道微生物群-血清素轴影响生理。这个项目的预期好处将是对调节我们健康的高度复杂的生理系统提供新的理解。

This project aims to understand how serotonin-producing cells in the gut interact with gut bacteria (the microbiome), using a combination of cells in culture and live germ-free and genetically modified mice. This project expects to generate new knowledge regarding cellular interactions that underlie important physiological pathways, such as the control of blood glucose and fat storage. The intended outcomes of this project are to identify how gut bacteria communicate with serotonin-producing cells to regulate metabolism, and whether diet acts via a gut microbiome-serotonin axis to impact physiology. The expected benefit of this project will be to provide a new understanding of highly complex physiological systems that regulate our health.