Understanding how bacteria adapt and function in the complex gut ecosystem

了解细菌如何在复杂的肠道生态系统中适应和发挥作用

• 批准号: FL210100258
• 负责人: Prof Dena Lyras
• 金额: $ 224.17万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL210100258
• 关键词: Understanding; how; bacteria; adapt; function

This project aims to investigate the role of the gut ecosystem in defining the structure and function of microbes. Given that one of the current challenges in microbiology is our inability to study individual microbes directly from complex, multi-microbial niches, this project aims to develop multidisciplinary methods to study microbes in their native state, to understand how they adapt to live in the gut. This understanding should provide fundamental insights into adaptation mechanisms that lead to bacterial proliferation, disease and antibiotic resistance. As well as enhancing interdisciplinary collaborations, this work should provide economic benefits by contributing to improved gut health of animals, and more efficient food production.

该项目旨在研究肠道生态系统在定义微生物结构和功能方面的作用。鉴于微生物学目前面临的挑战之一是我们无法直接从复杂的多微生物生态位中研究单个微生物，该项目旨在开发多学科方法来研究天然状态下的微生物，以了解它们如何适应生活在肠道中。这种理解应该为导致细菌增殖，疾病和抗生素耐药性的适应机制提供基本见解。除了加强跨学科合作外，这项工作还应通过改善动物肠道健康和提高粮食生产效率来提供经济效益。