Measurement and Modeling of Diect and Axon-Reflex Blood Flow Change elicited by Heat Stimulation for Pain Measurement

已经开发了一种测量系统来检查当热刺激施加到皮肤时疼痛感觉和血流量增加之间的相关性。通过新设计的接触式热刺激器（Kudo Electric Co.，疼痛分析仪NYT-9002），该测量系统可以使用两个激光流量计（Advance，ALF 2 1F）同时监测加热部位中心（部位C）和一个外周部位（部位P）的血流量。C部位的血流量通过透明的箔模中心清晰测量。部位P距离加热部位中心10 mm。C部位血流量增加的平均阈值范围为41.0-42.9 ℃，而P部位的平均值为43.8-44.7 ℃。C部位血流量增加的阈值明显低于烧灼感（轻度烧灼感，43.8 ~ 44.8 ℃; p<0.5），但P部位与烧灼感几乎相同。部位C处的血流增加具有6.4*2.5秒的潜伏期和938*585%的增加。C点的参数比P点的参数短而大（10.5* 2.9sec，799878%）。C部位血流量增加可视为加热引起的血管舒张反应，P部位血流量增加可视为轴突反射引起的血管舒张反应。存在两种类型的用于皮肤的热刺激的信号处理系统。

A measurement system has been developed to examine the correlation between pain sensation and blood flow increase when a heat stimulus was applied to the skin. The threshold for pain sensation on the surface of the forearm or the lower leg using localied heating via newly designed contact heat stimulator (Kudo Electric Co., Pain Analyzer NYT-9002), The measurement system can simultaneously moniter blood flow at the center of the heated site (site C) and at one of peripheral site (site P) using two Laser flowmeter(Advance, ALF2 1F). The blood flow at site C was clearly measured through the transparent center of the foil-themode. Site P was 10 mm away from the center of the heated site. The average threshold for a blood flow increase at site C ranged 41.0-42.9ﾟC, whereas the average at site P was 43.8-44.7ﾟC.The threshold for a blood flow increase at site C was significantly lower than that for a burning sensation (weak burning pain sensation, 43.8 - 44.8ﾟC ; p<0.5), but that at site P was almost the same as that for a burning sensation. The blood flow increase at site C had 6.4*2.5 sec latency and 938*585% increase. The parameters at site C were shorter and larger than those at site P (10.5*2.9 sec, 799 878%). The blood flow increase at site C can be taught as the vasodilatation dilrecytly elicited by heating, and one at site P as that evoked by axon reflex. There are two types of signal processing systems for heat stimulation of skin.