Nuclear and Electronic Dynamics of Microsolvated Biomolecules and Nanoparticle-Biomolecule Hybrid Systems driven by Tailored Laser Fields

在这个理论项目中，我们将探索和控制微溶剂化生物分子和生物分子与金属簇相互作用的耦合电子-核动力学，在不可缩放的尺寸范围内，添加或去除单个原子可以产生新的特性。其目的是了解激光驱动的生物分子与不同环境相互作用的多态动力学，并为设计新的功能生物生色团和基于纳米团簇的生物芯片提供理论基础。为此，我们将利用贵金属团簇独特的尺寸选择性光学和光电发射特性与生物分子的生物识别和功能相结合。此外，通过定制的激光场的最佳控制将被开发和建立作为一种工具，用于增强生物分析应用中涉及的生物分子响应。三个密切相关的主题将被调查：A）探索和控制的光动力学在微溶剂化的生物生色团，B）的理论设计的混合纳米团簇-生物分子的荧光生物芯片，和C）高次谐波产生（HHG）作为探针的核动力学在纳米团簇-生物分子混合系统。

In this theoretical project we will explore and control the coupled electron-nuclear dynamics of microsolvated biomolecules and of biomolecules interacting with metal clusters in the non-scalable size regime where adding or removing of a single atom can give rise to novel properties. The aim is to gain understanding of laser driven multistate dynamics in biomolecules interacting with different environments and to provide a theoretical basis for the design of new functional biochromophores and nanocluster based biochips. For this purpose we will exploit the unique size selective optical and photoemission properties of noble metal clusters combined with the biorecognition and functionality of biomolecules. Furthermore, the optimal control by tailored laser fields will be developed and established as a tool for the enhancement of the biomolecular response involved in bioanalytical applications. Three closely related topics will be investigated: A) exploration and control of photodynamics in microsolvated biochromophores, B) theoretical design of hybrid nanocluster-biomolecule based fluorescent biochips, and C) high harmonic generation (HHG) as probe for nuclear dynamics in nanocluster-biomolecule hybrid systems.