STUDY ON THE EXPRESSION FOR BIOACTIVITY OF NATURAL MEDICINENS ANALYZING BY THE FUNCTION OF MOLECULAR RECOGNITION FORMED FROM SUPRAMOLECULE.

考虑到分子识别，天然药物提取物中不溶性化合物对水的溶解度是可以理解的。我们用银杏酰基化黄酮苷构建了这个假设模型。该黄酮{山奈酚3- o - α -（6′′-对香豆醇葡萄糖基- β -1,2-鼠李糖苷）}的构象分析由Jinhai Gao等通过计算并结合n.o.e数据完成。他们描述了这种化合物的构象，并表明黄酮和香豆素基发色团彼此相邻，并与间隔物（鼠李糖和葡萄糖）相连。我们猜想由这两种发色团构成的空腔一定含有环糊精之类的东西。在这种考虑下，我们做了两个实验。第一个结果是该酰基化黄酮苷与自身结合形成二聚包合物，通过红外、紫外和CD光谱进行了鉴定。第二个结果是酰基化黄酮类苷与双叶碱形成包合物，这也通过几个光谱进行了估计。我们利用天然产物，也就是同一种植物的成分建立了超分子化学。

In consideration of the molecular recognition, solubility of insoluble compounds to water in the extract of natural medicines is understandable. We constructed this hypothetical model using acylated-flavone glycoside from Ginkgo biloba. The conformational analysis of this flavone {kaempferol 3-O-alpha- (6"'-p-coumaroylglucosyl-beta-1,2-rhamnoside)} was achieved by Jinhai Gao et al. by computational calculation accompanied with N.O.E.data. They described the conformation of this compound, and showed that flavone and coumaroyl chromophore faced each other side by side connecting with spacers (rhamnose and glucose).We supposed this cavity which was constructed from these two chromophores must include something like as cyclodextrine. Under this consideration, we tried two experiments. The first result was that this acylated-flavone glycoside was associated itself and formed dimerous inclusion compound, which was estimated by the IR, UV and CD spectra. The second result was that this acylated-flavone glycoside made a inclusion compound with bilobalide, which was also estimated by several spectra.We established the supramolecular chemistry using natural products, the components of the same plant.