The mechanism of primary-active transporters, light-driven ion channels and pumps studied by solid-state NMR (P06)

为了跨膜转运底物，转运蛋白在不同的时间和长度尺度上发生构象变化，并且通常需要在远域之间进行远距离通信。它们的功能与膜环境密切相关。我们将通过对ABC转运蛋白和视网膜结合蛋白家族的蛋白质应用固态核磁共振方法和生化方法来解决脂质双分子层中结构、功能和动力学的相互作用。

For translocating substrates across membranes, transport proteins undergo conformational changes at different times and length scales and often require long-range communication between distant domains. Their function is closely coupled to the membrane environment. We will address the interplay of structure, function and dynamics within the lipid bilayer by applying solid-state NMR methods and biochemical approaches to proteins from the ABC transporter and retinal binding protein families.