Genetics of Essential Hypertension.

我们发现血管紧张素转换酶基因的DD基因型和纤溶酶原激活物抑制剂-1基因的DD基因型与急性冠状动脉综合征的快速进展有关。由于单个基因对原发性高血压发生的贡献似乎很小，因此需要大量的受试者来明确确定某个基因是否真的对高血压起作用。通过对5000名受试者的大队列研究，我们发现前列环素合成酶基因是导致日本高血压的基因之一。我们已经通过建立基因大鼠确定了影响血压或肾血流动力学功能的基因座。通过使用这些数据进行比较作图，我们可能能够找到几个与人类原发性高血压有关的候选基因。

We have found that DD genotype of the angiotensin converting enzyme gene and DD genotype of the plasminogen activator inhibitor-1 gene are associated with rapid progression to acute coronary syndromes.Since contribution of a single gene to the genesis of essential hypertension appears to be small, a large number of subjects is necessary to clearly determine whether a gene really contributes to hypertension. Using a large cohort consisted of 5000 subjects, we have found that the prostacyclin synthase gene is one of the genes contributing to hypertension in Japanese.We have identified loci that influence blood pressure or renal hemodynamic functions by establishing congenic rats. From comparative mapping using these data, we may be able to find out several candidate genes contributing to human essential hypertension.