Metabolic evaluation using in vivo NMR spectroscopy for individual organs under serious conditions associated with reductive liver mitochondrial state

即使在严重的循环不良条件下，在慢性大鼠中的血凝性，在myocardium中的磷酸酶活性水平保持良好。在这种情况下，平均酮体比率（AKBR）下降，并发现了一个潜在的参数来评估系统代谢状态。We also applied型D131型D1P-and型D113型D1C-NMR spectroscopy together to examine the metabolic state of the liver。Furthermore，个体器官的代谢状态，如liver、心脏、大脑和骨骼肌肉，对使用Hemorrhagic Shock、内毒性冲击、myocardial Infarction、脑炎症、表皮和糖尿病动物模型进行核磁共振光谱检查。We incorporated ultra-fast echo planar imaging （EPI） technique into D11 D1H-NMR spectroscopic imaging。We have alre？reported fast D113型D1C metabolite mapping derived from D113型D1C-glucose in rat focal brain ischemia。These NMR spectroscopic techniques were also applied to the clinical cases。在患有糖尿病阴道的患者中，我们在与骨骼肌肉相关的基础上发现了代谢异常现象。这一发现明显地不同于它与迷幻症的不同。对于心脏病，D131 D1 P核磁共振光谱仪during hand-grip练习已经找到可以用来判断myocardium的可行性。在大脑研究中，D11-D1 H核磁共振光谱仪被携带出对阴道瘤的恶性潜能的判断，对myotonic dystrophy的病理学条件，光谱仪在光学刺激期间被用于对锂或电子刺激疗法的影响的预测。快速核磁共振光谱成像技术也可适用于临床案例。

Even in severe circulatory insufficient conditions during hemorrhage in jaundiced rats, the phosphoenergetic level in the myocardium was maintained fairly well. In such conditions, arterial ketone body ratio (AKBR) decreased and it was found to be a potential parameter to evaluate the systemic metabolic state. We also applied ィイD131ィエD1P- and ィイD113ィエD1C-NMR spectroscopy together to examine the metabolic state of the liver. Furthermore, the metabolic states of individual organs, such as liver, heart, brain and skeletal muscles, were investigated with NMR spectroscopy using hemorrhagic shock, endotoxic shock, myocardial infarction, brain infarction, epilepsy and diabetic animal models. We incorporated ultra-fast echo planar imaging (EPI) technique into ィイD11ィエD1H-NMR spectroscopic imaging. We have already reported fast ィイD113ィエD1C metabolite mapping derived from ィイD113ィエD1C-glucose in rat focal brain ischemia.These NMR spectroscopic techniques were also applied to the clinical cases. In patients with diabetic gangrene, we found metabolic abnormalities in the skeletal muscles associated with increased pII. Such findings were clearly different from that with ischemia. For heart disease, ィイD131ィエD1P NMR spectroscopy during hand-grip exercise was found to be useful to judge the viability of myocardium. In brain research ィイD11ィエD1H NMR spectroscopy was carried out for the judgment of malignant potential of maningioma, the pathophysiologic condition of myotonic dystrophy, spectroscopy during photic stimulation was used for the prediction of the effects of lithium or electrical stimulation therapy for bipolar disorder. Fast NMR spectroscopic imaging technique could be also applicable with clinical cases.