MOLECULAR ENVIRONMENT OF THE ACTION SITE OF ANESTHETICS

自从麻醉机制的研究开始以来，一百多年已经过去了。奥弗顿的脂类理论一直是物理化学家在这一领域中最基本的理论。然而，这一理论只涉及麻醉分子如何存在于作用部位，并没有解释其作用机制。为什么影响脂膜理化参数的麻醉药浓度远高于临床浓度？另一方面，在临床浓度下可以观察到麻醉剂对蛋白质的一些影响。因此，使用蛋白质如神经递质和/或受体来研究麻醉机制正变得流行。关于麻醉剂对蛋白质的“特异性”作用，已经发表了许多论文，为了获得一个有价值的理论，需要对广泛的研究进行分析。因此，继续进行理化研究和生化研究是很重要的。该项目包括物理化学和生物化学研究人员。在项目期间，我们多次会面，讨论了麻醉剂作用部位周围的环境。为了扩大讨论，我们举办了一个国际研讨会。我们邀请了许多麻醉机理领域的研究人员，进行了一次很有意义的讲座。

More than a hundred years have passed since the study of mechanisms of anesthesia began. Overton's lipid theory has been the most fundamental theory for physicochemists in this field. However, this theory only dealt with how the anesthetic molecules exist in the action site, and did not explain the mechanisms of their action. Why are the concentrations of anesthetics that affect the physicochemical parameters of lipid membranes much higher than the clinical concentrations? On the other hand some effects of anesthetics on proteins can be observed at clinical concentrations. Therefore the use of proteins such as neurotransmitters and/or receptors for the study of anesthetic mechanisms is becoming popular. There have been many papers published regarding the "specific" action of anesthetics on proteins.In order to obtain a valuable theory, it is necessary to analyze a wide range of research. Therefore, it is important to continue physicochemical studies as well as biochemical studies. This project includes both physicochemical and biochemical investigators. During the project, we met together several times and discussed about how the environment around anesthetic at the action site is. To extend the discussion, we held an international workshop. Inviting many researchers from various fields concerning anesthetic mechanism, we have had a very meaningful talk.