Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex
Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex
批准号:
25221204
负责人:
Takahashi Shin-Ichiro
金额:
$138.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2013
资助国家:
日本
项目状态:
已结题
起止时间:
2013-05-31 至 2018-03-31
中文摘要
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英文摘要
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Mechanisms underlying hepatic steatosis induced by total dietary amino acid deficiency and arginine only deficiency; Novel amino acid signals inducing insulin-like activities.
膳食总氨基酸缺乏和仅精氨酸缺乏引起的肝脂肪变性的机制;
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Hiroki Nishi, Daisuke Yamanaka, Yuki Goda, Haruka Nagata, Sara Fukushima, Yuka Toyoshima, Fumihiko Hakuno, Shin-Ichiro Takahashi]
通讯作者:
Shin-Ichiro Takahashi
PI 3-kinase-binding protein PI3KAP plays an important role in cell migration and is required for embryogenesis in zebrafish.
PI 3 激酶结合蛋白 PI3KAP 在细胞迁移中发挥重要作用,并且是斑马鱼胚胎发生所必需的。
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[Kawauchi H., Yamanaka D., Kamei H., Hakuno F., Minami S., Chida K., Takahashi S.]
通讯作者:
Takahashi S.
Protein malnutrition increases the amount and phosphorylation of 4E-binding protein 1 (4E-BP1) to accumulate lipid in rat liver.
蛋白质营养不良会增加 4E 结合蛋白 1 (4E-BP1) 的数量和磷酸化,从而在大鼠肝脏中积聚脂质。
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[Toyoshima Y, Tokita R, Taguchi Y, Yoshizawa F, Takahashi S, Kato H, Minami S]
通讯作者:
Minami S
Discovery of novel anti-diabetic drugs by interrupting the association between DGKζ and IRS-1
通过中断 DGK z 和 IRS-1 之间的关联发现新型抗糖尿病药物
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Bu-Chin Yu, Akihiro Ito, Minoru Yoshida, Yasutoshi Ando, Tin-Yu Liu, Fumihiko Hukuno, Kazuhiro Chida , Shin-Ichiro Takahashi.]
通讯作者:
Shin-Ichiro Takahashi.
Insulin receptor substrates (IRSs), interacting with Ras-GAP SH3-domain-binding protein 1 (G3BP1), regulate cap-independent translation
胰岛素受体底物 (IRS) 与 Ras-GAP SH3 结构域结合蛋白 1 (G3BP1) 相互作用,调节帽独立翻译
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Yuuri Nakaoki, Atufumi Ozoe, Meri Yonezawa-Sone, Toshiaki Fukushima, Kazuhiro Chida, Fumihiko Hakuno, Naoyuki Kataoka, and Shin-Ichiro Takahashi]
通讯作者:
and Shin-Ichiro Takahashi
共 140 条
Regulatory mechanism of ubiquitin modification of insulin receptor substrates and its physiological and pathological significance.
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批准号:18H03972
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$28.37万
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财政年份:2018
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负责人:Takahashi Shin-Ichiro
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依托单位:
Elucidation of molecular mechanisms of alternative splicing of insulin receptor RNA and its physiological significance
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批准号:15K14840
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2015
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负责人:Takahashi Shin-Ichiro
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依托单位:
海外基金