Deciphering novel cross-talk between innate cytokine receptors

了解干扰素的基本功能，以及它们如何向细胞发出信号，是理解基本免疫的核心。干扰素是免疫系统的关键分子，对正常细胞发育很重要，它们保护身体免受病毒感染和癌症的侵害，但在不同的自身免疫性疾病和创伤环境中可能是有害的。初步数据显示，存在一种以前被忽视的干扰素信号传导途径。该项目旨在了解这一途径是如何工作的，以及它如何促进细胞的正常工作。这一基础科学对疫苗的设计和干扰素信号缺陷疾病的治疗方法的设计具有未来的影响。

Understanding the basic functions of interferons, how they signal to cells, is central to understanding fundamental immunity. Interferons are crucial molecules of the immune system that are important for normal cell development and they protect the body from viral infection and cancer but can be deleterious in different autoimmune diseases and trauma settings. Preliminary Data shows there is a pathway of interferon signalling that has previously been overlooked. This project aims to understand how this pathway works and how it contributes to the normal workings of cells. This fundamental science has future consequences for the design of vaccines and for the design of therapeutics to treat diseases that show defective interferon signalling.