Validation Of Novel Nutrient Formulation For Appetite Regulation

自1984年以来，我们的科学小组率先研究了我们的肠道如何感知一顿饭的内容。这项研究在今年发表的一篇重要论文中达到了高潮，论文显示我们发现了一种新颖而有效的方法来降低肥胖者的食欲。我们公司Enterika的成立是为了将这一发现作为一种产品推向市场，然后可以用于满足非常大的未得到满足的需求--食欲抑制和减肥。一段时间以来，人们已经知道，肠道不同部分的特殊细胞可以通过肠壁细胞外部的特殊受体(分子)来感知不同的营养物质。我们的发现是，将某些营养物质专门定位于较低的肠道(结肠)会通过激活一些特定的传感器分子来抑制食欲。反过来，这些细胞将荷尔蒙释放到血液中，激活感觉神经，从而抑制食欲。我们发现的一个关键部分是不同的营养物质通过不同的分子起作用，只有将不止一种营养物质的作用结合在一起，我们才能刺激这一过程。另一个重要的发现是，自然产生的饮食营养素在少量触发这种反应方面是有效的。这意味着我们的方法是不含药物的，安全的，可以有更广泛的健康益处。我们的产品目前由充满纯营养的胶囊组成，胶囊上覆盖着一层保护层，只有当它到达结肠时才会分解。然而，每顿饭之前都需要很多胶囊。我们的目标是改进这个配方(基于药理学的最新进展)，这样它就更小了，但仍然有效。这将需要更多的实验室工作来确保激素释放途径得到充分激活，并需要对肥胖者进行临床研究，以检查胶囊是否达到了诱导激素变化和抑制食欲的目的。我们将继续进一步精简和优化，直到我们拥有最好的产品。据我们所知，没有其他公司或机构采用我们所选择的方法。因此，我们处于一个理想的位置，可以采取这两个明确的步骤，在减肥治疗市场占据相当大和成功的一部分。

Our scientific group has pioneered research on how our gut senses the contents of a meal since 1984\. This research has culminated in a major paper published this year showing our discovery of a novel and effective means to reduce appetite in obese people. Our company, Enterika, was set up to take this discovery to the market as a product that could then be made available for a very large unmet need -- appetite suppression and weight loss.For a while, it has been known that specialised cells in various parts of the intestine can sense different nutrients by specialised receptors (molecules) on the outsides of the cells lining the intestine wall. Our discovery was that targeting certain nutrients specifically to the lower gut (colon) gives rise to appetite suppression by activation of some of these specific sensor molecules. In turn, these cells then release hormones into the blood stream and activate sensory nerves leading to appetite suppression. A critical part of our discovery was that different nutrients act via different molecules, and only by combining the actions of more than one nutrient could we stimulate this process. Another critical finding was that naturally occurring dietary nutrients are effective in triggering this response in small quantities. This means our approach is drug-free, safe and could have broader health benefits.Our product currently consists of capsules filled with pure nutrient coated with a protective layer that only breaks down when it reaches the colon. However, many capsules are required before each meal. We aim to refine this formulation (based on recent advances in pharmacology) so it is smaller but still as effective. This will take more lab work to ensure the pathway of hormone release is adequately activated, and a clinical study in obese subjects to check that the capsules achieve their aim of inducing hormone changes and suppressing appetite. Further streamlining and optimisation will continue until we have the best product.To our knowledge, no other company or institution is pursuing the approach we have chosen. We are therefore in an ideal position to take these two clear steps towards occupying a substantial and successful part of the anti-obesity treatments market.