Affect, Mind-Body Factors, and Eating Behaviors: Examining Naturalistic Associations among Female Young Adults with Eating Disorder Symptoms

项目总结/摘要 进食障碍（ED）是一种使人衰弱的精神疾病，与死亡率升高有关 风险和发病率。令人不安的是，超过一半的人谁接受辅助支持的艾德治疗 仍然是症状性的，理论上这是一种局限性，源于大多数艾德治疗缺乏或不重视 声称是ED发生和维持的基础的因素，包括：（1）内感受;（2） 正念;（3）情绪调节（即，身心因素）。值得注意的是，现有的经验工作和我的研究 与年轻女性间接支持中介作用，这三个身心因素内建立 情感与饮食行为之间的关系然而，迄今为止，身心因素还没有被明确地 被评估为情感与艾德症状成人使用 两者都是无序的（即，艾德）和促进健康的饮食行为（即，吃东西，吃东西， 生理饥饿和饱足的线索）通过生态瞬时评估（EMA）和心理生理 方法.这项拟议的研究将解决亚临床和临床的女性年轻人之间的这些差距。 艾德症状（N = 237），他们将完成基于实验室和EMA的任务。基于实验室的任务将包括：（1）a 基线调查评估情感的特质水平、身心因素和饮食行为;（2）ECG 同步测量EEG心跳诱发脑电位的心跳感知任务（目的 内感受的测量）。然后，参与者将在智能手机上完成为期14天的EMA调查 针对情绪的状态水平，身心因素和饮食行为。值得注意的是， 成分将使我们能够加强对影响，身心因素，饮食， 通过使用多模态评估的行为关联;使用EMA将使我们能够回答新的研究 这些关联在日常生活中的时间顺序问题。拟议的研究将涉及 两个目的：（1）检查身心因素是否介导和/或调节 差异效价的情感体验，以及日常生活中使用艾德和IE行为;（2）检查是否 不同的内感受维度调节正念和情绪失调之间的关联， 日常生活中的艾德与IE行为使用。这项研究可以为ED确定可行的预防和治疗目标 根据NIMH的战略目标3（努力预防和治疗），不仅可以帮助年轻人， 具有艾德症状的妇女减少不良健康行为（即，艾德行为）但变得良好（即，通过 增加行为）。通过开展这项研究和培训计划，申请人将开发 她的培训的中心目标不可或缺的能力：建立一个独立的研究实验室， 学术机构，旨在提高对ED发病机制中涉及的因素的理解， 其长期目标是提高艾德治疗效果。

Project Summary/Abstract Eating disorders (EDs) are debilitating mental illnesses that are associated with heightened mortality risk and morbidity. Disconcertingly, over half of individuals who receive empirically-supported ED treatments remain symptomatic, a limitation theorized to stem from most ED treatments’ lack of or peripheral emphasis on factors purported to underlie the onset and maintenance of EDs, including deficits in: (1) interoception; (2) mindfulness; (3) emotion regulation (i.e., mind-body factors). Of note, existing empirical work and my research with young women indirectly support the intermediary role of these three mind-body factors within established relationships between affect and eating behavior. Yet, to date, the mind-body factors have not been explicitly assessed as mediators or moderators of relationships between affect and adults with ED symptoms’ use of both disordered (i.e., ED) and health-promoting eating behaviors (i.e., intuitive eating [IE], eating based on physical hunger and satiety cues) via ecological momentary assessment (EMA) and psychophysiological methods. The proposed study will address these gaps among female young adults with subclinical and clinical ED symptoms (N = 237), who will complete lab-based and EMA tasks. Lab-based tasks will include: (1) a baseline survey assessing trait-levels of affect, the mind-body factors, and eating behaviors; (2) an ECG heartbeat perception task with concurrent measures of EEG heartbeat-evoked brain potentials (objective measures of interoception). Participants will then complete surveys on smartphones for a 14-day EMA period that target state-levels of affect, the mind-body factors, and eating behaviors. Notably, the lab-based component will allow us to strengthen the validity of inferences made about affect, mind-body factor, eating behavior associations via use of multimodal assessment; use of EMA will allow us to answer novel research questions about the temporal sequencing of these associations in daily life. The proposed study will address two Aims: (1) Examine whether the mind-body factors mediate and/or moderate associations between differentially valenced affective experiences, and use of ED and IE behaviors in daily life; (2) Examine whether distinct interoception dimensions moderate associations between mindfulness and emotion dysregulation, and ED vs. IE behavior use in daily life. This research can identify viable prevention and treatment targets for EDs that, in line with the NIMH’s Strategic Objective 3 (Strive for Prevention and Cures), may not only help young women with ED symptoms decrease adverse health behaviors (i.e., ED behaviors) but become well (i.e., by increasing IE behaviors). By conducting this research and training plan, the applicant will develop competencies integral to the central aim of her training: to establish an independent research lab at an academic institution that seeks to improve the understanding of factors implicated in the pathogenesis of EDs, with the long-term goal of enhancing ED treatment efficacy.