Microbiome Function in Atopic Dermatitis

摘要/摘要 特应性皮炎是一种常见的炎症性皮肤病。最近的观察强烈表明 AD患者皮肤上存在的异常微生物群是影响AD发病的主要因素 这种疾病的严重性和慢性性质。特别是，金黄色葡萄球菌促进表皮屏障 并加剧局部和全身免疫反应。在健康的受试者中，有益 皮肤微生物群的成员可以限制金黄色葡萄球菌的生长，但这些有益的细菌 患有阿尔茨海默病的成年人身上缺少菌株。这个项目试图理解为什么患有AD的成年人缺乏有益的 通过研究人葡萄球菌原型菌株在AD皮肤上的存活情况。 将测试改善其存活率的干预措施，并将在儿童AD人群中应用 已评估。总体而言，成功完成该ADRN临床研究中心的拟议目标将 增进对AD的理解，并提供必要的信息来开发创新的新产品 基于微生物群靶向治疗的治疗方法。

Summary/Abstract Atopic dermatitis (AD) is a common inflammatory skin disease. Recent observations strongly suggest that the abnormal microbiome present on the skin of subjects with AD is a major factor that influences the severity and chronic nature of this disorder. In particular, Staphylococcus aureus promotes epidermal barrier dysfunction and exacerbates the local and systemic immune response. In healthy subjects, beneficial members of the skin microbiome act to limit the growth of Staphylococcus aureus but these beneficial bacterial strains are missing on adults with AD. This project seeks to understand why adults with AD lack beneficial bacterial strains by study of the survival of a prototype strain of Staphylococcus hominis on AD skin. Interventions to improve its survival will be tested, and application in the pediatric AD population will be evaluated. Overall, successful completion of the proposed aims of this ADRN Clinical Research Center will advance understanding of AD and provide essential information to permit development of an innovative new therapeutic approach based on targeted microbiome therapy.