Interactive Omics of HepB Vaccine Response in Co-Infection with Parasites

摘要： 行政补编的目标是提供丰富的中央数据和样本。 来自宾夕法尼亚州雷丁和俄亥俄州克利夫兰的两个独立队列。这个 样本和临床数据将被分发到该计划分配的中央核心 在那里将进行标准化的表型分析。核心的一般领导将是 由德雷克塞尔大学的查尔斯·凯恩斯博士和贝尼尼奥博士为雷丁队列提供 来自凯斯西储大学。 本行政副刊有三个目的。 具体目标1：向我们所有的人提供生物标本(PBMC、痰和灌洗液) 指定的核心，以表征免疫表型和免疫状态 对新冠肺炎感染的反应。 具体目标2：提供临床数据(CBC计数、临床测试、成像)给所有指定的 核心以建立与免疫状态和疾病进展的相关性 具体目标3：向我们指定的实验室提供生物标本和临床数据 德雷克塞尔大学和凯斯西部大学。这些实验室将执行独特的分析，而不是 由该计划的核心实验室覆盖。

Summary: The goal of the Administrative Supplement is to provide a central rich store of data and specimens from two independent cohorts located in Reading, Pennsylvania and Cleveland, Ohio. The samples and the clinical data will be distributed to the central cores assigned by the program where standardized phenotypic assays will be performed. General leadership of the Cores will be provided by Dr. Charles Cairns from Drexel University for the Reading cohort and Dr. Benigno from Case Western Reserve University. There are 3 aims of this Administrative supplement. Specific Aim 1: To provide biological specimens (PBMCs, sputum, and lavages) to all our designated cores in order to characterize the immunophenotypes and the immune status and response to COVID-19 infection. Specific Aim 2: To provide clinical data (CBC counts, clinical tests, imaging) to all our designated cores in order to establish correlation with immune status and disease progression Specific Aim 3: To provide biological specimens and clinical data to our assigned laboratories at Drexel and Case Western Universities. These laboratories will perform unique assays that are not covered by the core laboratories of the program.