PrEParados: A Multi-Level Social Network Model to Increase PrEP Enrollment by Latino MSM Self-Identified as Gay, Bisexual

项目总结 PrEParados是一项为期三年的R01发展研究，将确定社交网络如何影响PrEP 拉丁裔男男性行为者(LMSM)的接受和依从性，两人都认为自己是 同性恋，以及自我认同为双性恋/异性恋的未经研究的LMSM群体。这项研究将在#年实施。 迈阿密-戴德县(迈阿密)，美国艾滋病毒流行的中心。在中国的种族/民族中 迈阿密的LMSM是艾滋病发病率最高的城市。尽管预防接种计划是最有效的艾滋病毒预防措施 目前，迈阿密符合条件的LMSM很少有人参加PrEP计划(2018年只有6%)。我们的 初步研究(N=130)表明，社交网络结构可能是导致LMSM低PrEP的原因 使用。在对LMSM自我认定为同性恋研究中，我们发现很大比例的性接触 涉及双性恋/异性恋LMSM。自我认同的双性恋/异性恋LMSM是MSM与谁之间的桥梁 艾滋病毒的流行集中在迈阿密的普通人群中。在制定干预措施之前，我们 需要实施此R01，它研究更大的样本以确定网络配置和动态 LMSM的性别自我认同(男同性恋或双性恋/异性恋)对艾滋病毒风险的影响。通知未来 干预，我们的研究将考察社交网络结构因素如何抑制或促进访问， 鼓励、吸收和坚持PrEP。这些调查结果将使更好地部署Accurate 信息和干预，导致LMSM更多地启动和遵守PrEP。 PrEParados将研究三个社交网络：1)友谊网络--识别社交网络机制 在迈阿密的LMSM朋友中推广PrEP的使用。2)性网络--区分同性恋和异性恋 与性伴侣之间的PrEP交流相关的并向特性和动力学。3)场地 网络-确定可以增加PrEP知识的地理和在线场所的从属关系。 我们与拉丁裔Salud、迈阿密-戴德县卫生局PrEP诊所和 迈阿密大学的流动PrEP诊所和快速访问健康诊所将提供8000+ LMSM，包括1500多名PrEP用户和500多名自我认同为双性恋/异性恋的人。这项R01研究将 提供新信息，允许PrEP干预包括社交网络组件和 根据LMSM的性别自我认同量身定做。这些新的干预措施可以作为 针对来自其他难以接触到的人群的男性的预备计划。

PROJECT SUMMARY PrEParados is a three-year developmental R01 study that will determine how social networks impact PrEP uptake and adherence among Latino men who have sex with men (LMSM), both those who self-identify as gay, and the unstudied group of LMSM who self-identify as bisexual/straight. This study will be implemented in Miami-Dade County (Miami), the epicenter of the HIV epidemic in the US. Among racial/ethnic groups in Miami, LMSM have the highest HIV incidence. Despite PrEP being the most effective HIV prevention measure currently available, few eligible LMSM in Miami are enrolled in a PrEP program (only 6% in 2018). Our preliminary study (N=130) suggests that social network structures may be contributing to LMSM’s low PrEP use. In that study of LMSM self-identified as gay, we discovered a large proportion of sexual encounters involved bisexual/straight LMSM. Self-identified bisexual/straight LMSM are a bridge between MSM—in whom the HIV epidemic is concentrated—and the general population in Miami. Before developing interventions, we need to implement this R01, which studies a larger sample to identify network configurations and dynamics impacting HIV risk among LMSM by their sexual self-identification (gay or bisexual/straight). To inform future interventions, our study will examine how social network structural factors suppress or promote access, encouragement, uptake, and adherence to PrEP. These findings will allow better deployment of accurate information and interventions, resulting in increased PrEP initiation and adherence amongst LMSM. PrEParados will study three social networks: 1) Friendship Networks—to identify social network mechanisms that promote PrEP use among LMSM friends in Miami. 2) Sexual Networks—to distinguish homophily and dyadic characteristics and dynamics associated with PrEP communication between sexual partners. 3) Venue Networks—to determine affiliations with geographic and online venues that could increase PrEP knowledge. Our established partnerships with Latinos Salud, Miami-Dade County Health Department PrEP Clinic, and the University of Miami’s Mobile PrEP Clinic and Rapid Access Wellness Clinic will provide access to 8,000+ LMSM, including 1,500+ PrEP users and 500+ who self-identify as bisexual/straight. This R01 study will provide new information that will allow PrEP interventions to include social network components and be tailored based on LMSM’s sexual self-identification. These new interventions could then serve as models for PrEP programs targeting males from other hard to reach populations.