HIV CENTERS FOR UNDEREPRESENTED POPULATIONS IN RESEARCH CTU (HIV CURE CTU) Administrative Supplement

项目摘要： COVID-19是一种由SARS CoV-2病毒引起的疾病，这是一种新型冠状病毒， 由于普通人群缺乏对病毒的免疫力， 疗法COVID-19疾病导致的发病率增加发生在65岁以上的人群中， 老年人、高血压、糖尿病、慢性肺病和免疫缺陷患者。 COVID-19疾病极大地影响了美国的有色人种， 有色人种中合并症的患病率，以及由于相对缺乏医疗服务， 对有色人种的照顾，特别是在该国受贫困和缺乏教育影响最大的地区。 医疗补助的扩张，比如美国南部的一些州，比如德克萨斯州， 是全国未参保人数最多的国家德克萨斯州目前有45，198例病例 1,272人死亡。哈里斯县/休斯顿已经确认了9，050人 死亡199例。 COVID-19大流行与目前影响美国的艾滋病毒大流行同时发生， SARS CoV-2和HIV在有色人种社区造成高发病率。除了影响 无论是病毒感染，还是公共卫生方法对社会经济和心理健康的影响， 为了控制COVID-19疾病的传播，社交距离，隔离和隔离， 对艾滋病毒感染者的精神影响超过对一般人口的影响。 心理健康问题、贫困、粮食不安全、经济脆弱性、服务性工作 就业机会被淘汰的行业，失学儿童缺乏安全网， 对艾滋病毒感染者的影响尤为严重。 德克萨斯州儿童医院（TCH）的提案将解决COVID-19对儿童的影响 以及休斯顿地区的艾滋病毒感染者。TCH将评估流行的SARS CoV-2 通过在基线和6个月内对160名儿童和青少年进行PCR评估， 年龄2至24岁，在TCH接受护理。还将评估SARS CoV-2的血清学 在基线和6个月内观察该人群中免疫力随时间的变化。调查 将在基线和6个月时进行评估，以评估社会经济和心理 社交距离对这些家庭和青少年的健康影响。2019冠状病毒病患者 艾滋病病毒感染将被描述。基线和随访人口统计学、免疫学、 社会经济和心理健康特征的儿童和青年登记生活在 艾滋病毒将被描述。

Project Summary: COVID-19 is a disease caused by SARS CoV-2 virus, a novel coronavirus that has caused a pandemic due to lack of immunity to the virus in the general population and lack of effective therapy. Increased morbidity due to COVID-19 disease occurs in people age 65 years old and older, persons with hypertension, diabetes, chronic lung disease, and with immunodeficiency. COVID-19 disease has greatly impacted persons of color in the United States due to a high prevalence of comorbidities in persons of color and due to relative lack of access to medical care in persons of color, especially in areas of the country most impacted by poverty and lack of Medicaid expansion, such as some Southern states in the US, like Texas, which has the one of the highest rates of uninsured individuals in the country. Texas currently has had 45,198 cases of COVID-19 with 1,272 fatalities. Harris County/Houston has had 9,050 combined confirmed cases with 199 deaths. The COVID-19 pandemic coincides with the HIV pandemic currently impacting the US and both SARS CoV-2 and HIV cause high morbidity in Communities of Color. Aside from the impact of both viral infections, the socioeconomic and mental health impacts of the public health approach to controlling the spread of COVID-19 disease, social distancing, quarantine, and isolation, have detrimentally impacted persons with HIV over and above the effects on the general population. Mental health problems, poverty, food insecurity, economic vulnerability, work in service industry where jobs have been eliminated, and lack of safety net for children out of school, all disproportionately affect persons with HIV. The Texas Children's Hospital (TCH) proposal will address the impact of COVID-19 in children and youth living with HIV in the Houston area. TCH will evaluate for prevalent SARS CoV-2 infection by performing a PCR evaluation at baseline and in 6 months in 160 children and youth ages 2 to 24 years who receive care at TCH. Serology for SARS CoV-2 will also be evaluated at baseline and in 6 months to look for evolving immunity over time in this population. Surveys will be administered at baseline and 6 months to evaluate for the socioeconomic and mental health impact of social distancing on these families and youth. COVID-19 disease in persons with HIV infection will be described. Baseline and follow-up demographic, immunologic, socioeconomic, and mental health characteristics of the children and youth enrolled living with HIV will be described.