(REDS-IV-P) RECIPIENT EPIDEMIOLOGY AND DONOR EVALUATION STUDY IV-DOMESTIC HUBS

REDS计划的目标是评估和改善血液供应的安全性和可用性，以及输血疗法的安全性和有效性。该计划还致力于主动应对国家血液供应面临的潜在新威胁，并作为正在进行的输血研究工作的资源。目前处于第四阶段，受者流行病学和捐赠者评估研究-IV-儿科(REDS-IV-P)计划主要旨在改善输血的好处，同时降低其风险；REDS计划还将新的重点放在以前研究不足的人群上。 在过去的30年里，REDS一直是美国在血液采集和输血安全方面的首要研究项目。在其第三阶段-REDS-III-该计划侧重于对输血链的所有要素进行研究，从献血者到他们献血制成的血液产品，再到通过输血接受产品的成年患者。 REDS-IV-P建立在REDS-III的基础上，额外关注需要输血的新生儿、儿童和孕妇的研究。在REDS-IV-P中汇编的数据将使研究人员能够快速解决输血医学中的关键研究问题，并为成人以及儿童和其他未被研究的患者群体的血液政策决策提供信息。 REDS-IV-P还扩大了在REDS-III中建立的巴西镰状细胞疾病队列，以评估镰状细胞疾病的输血做法和相关的临床结果。REDS-IV-P巴西输血计划还将继续监测和监测寨卡病毒、基孔肯雅热、登革热和其他新出现的对血液供应的病毒威胁。 这一修改的目的是为2020财年NICHD预留资金，以支持国内中心，适度的安全环境，并支持任何第一阶段的儿科/新生儿工作。

The goal of the REDS program is to evaluate and improve the safety and availability of the blood supply and the safety and effectiveness of transfusion therapies. The program also works to proactively address potential emerging threats to the Nation's blood supply and serves as a resource for ongoing work in transfusion research. Now in its fourth phase, the Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) program aims primarily at improving the benefits of transfusion while reducing its risks; the REDS program also has a new focus on previously understudied populations. Over the past 30 years, REDS has been the premier research program in blood collection and transfusion safety in the United States. In its third phase — REDS-III — the program focused on conducting research on all elements of the transfusion chain, from the blood donor to the blood products made from their donation to the adult patients receiving the products through transfusion. REDS-IV-P builds on REDS-III with an additional focus on research with newborns, children, and pregnant women who need transfusions. The data compiled in REDS-IV-P will allow investigators to rapidly address key research questions in transfusion medicine and inform blood policy decisions, for adults as well as for children and other understudied patient populations. REDS-IV-P also extends the Brazilian sickle cell disease cohort that was established in REDS-III to evaluate transfusion practices and associated clinical outcomes in sickle cell disease. The REDS-IV-P Brazilian transfusion program will also continue its monitoring and surveillance efforts for Zika, chikungunya, dengue, and other emerging viral threats to the blood supply. The purpose of this modification is to obligate FY 2020 NICHD funds to support the Domestic Hubs moderate security environment and support any Phase 1 pediatric/neonatology efforts.