Auditory & Integrative Functions of the Prefrontal Cortex DIVERSITY SUPPLEMENT

摘要 在这份多样性补充材料中，我们建议对候选人进行一年的研究和培训 在丽莎白·罗曼斯基博士的实验室里进行研究。三个实验是 建议。在补充性实验1中，考生将考察中间人的角色 前额叶皮质在性能监测和错误检测中的作用。为了做到这一点，他将训练实验对象 来完成一个更难的视听工作记忆任务。这将允许 检查错误和增加难度时的神经活动。在实验2中， 考生将使用Oddball任务来确定腹侧前额叶集合是如何检测到 不一致的视听刺激对。使用这一易于培训的任务将允许测试 比传统的工作记忆范式多得多的刺激对。在实验3中， 面孔-发声交流刺激的时间约束将通过改变 听觉和视觉成分的SOA值，并记录腹侧的预期变化 前额叶神经元对这些异步性的反应。这些研究的结果将告诉我们这一角色 前额叶皮质在检测和整合交流信息的特定特征中的作用 它们与刺激的语境相关性和时间的重要性直接相关 发声信息与相关的口腔运动之间的关系。这些实验是合乎逻辑的 延长父母拨款期限，是从以下方面获得更多信息的有效途径 我们实验室里已经有了宝贵的资源。

SUMMARY In this diversity supplement we are proposing a year of research and training for the candidate to perform research in the laboratory of Dr. Lizabeth Romanski. Three experiments are proposed. In supplemental experiment 1, the candidate will examine the role of the medial prefrontal cortex in performance monitoring and error detection. To do this he will train subjects to perform a more difficult version of the audiovisual working memory task. This will allow for the examination of the neural activity during errors and increased difficulty. In Experiment 2, the candidate will use the Oddball task to determine how ventral prefrontal ensembles detect incongruent audiovisual pairs of stimuli. Use of this easy-to-train task will allow the testing of many more stimulus pairs than traditional working memory paradigms. In Experiment 3, the temporal binding of face-vocalization communication stimuli will be examined by altering the SOA of the auditory and visual components and recording the expected change in ventral prefrontal neurons to these asynchronies. The results of these studies will inform us of the role of prefrontal cortex in detecting and integrating specific features of communication information that are directly related to contextual relevance of stimuli and the importance of the temporal relationship of vocal information and associated mouth movements. The experiments are logical extensions of the parent grant and are an efficient approach to gaining more information from valuable resources already in place in our laboratory.