Behavioral Sleep Medicine: Training in Sleep and Aging

行为睡眠医学：睡眠与衰老训练 摘要 目标：在本提案中，Michael Perlis博士请求支持：1）稳定和扩大他对初级教育的指导 行为睡眠医学领域和生物心理社会学方法的研究人员， 失眠症（病因学、病理生理学、治疗结果研究和治疗作用机制 （2）参与一项教育活动计划，为他和他的学员提供一个强大的 为评估衰老作为失眠研究的调节因素奠定基础; 3）建立一个 与初级研究人员建立合作网络，在NIA支持下进行假设驱动的研究 失眠症的自然史背景：Perlis博士参与了以患者为导向的 从20多岁就开始做研究他一直是杰出导师的受益者， 这一传统贯穿了他的整个职业生涯。他对精神障碍的研究从基础研究延伸到 以病人为中心的研究。资格：候选人具有丰富的PI，Co-PI或Co-I经验， 多次获得NIH奖项，并通过NIH K23和R21机制成功指导他人。 环境：宾夕法尼亚大学（Penn）是睡眠和时间生物学的主要中心之一。 研究和临床工作。因此，它有很多提供双方的PI和他的学员。发展活动： 导师专业发展的核心活动是每月举办一次研讨会 关注睡眠和衰老的系列。领先的科学家将被邀请到宾夕法尼亚大学讨论他们的想法， 关于衰老对睡眠需求、睡眠能力和睡眠机会的影响，以及 这些领域增加了睡眠障碍和不良健康结果的风险。此外该 导师/PI将每年参加一次研讨会或课程，重点是老龄化的生物心理社会观点， 一个关于生物伦理学的讲习班。导师计划：作为宾夕法尼亚大学行为睡眠医学主任 计划，Perlis博士创造了一套独特的教育活动，吸引了广泛的学员 包括已建立的专业人员、初级研究人员、博士后研究员、研究生和医科学生， 学士后和本科生。K24的计划是为学员提供一套教育 活动包括专业发展，行为睡眠医学的重点培训，以及深入的 关于睡眠连续性的定量评估的评价（例如，睡眠日记评估， 活动记录仪、PSG和QEEG）。研究：候选人提议创建一个协作网络， 档案分析与Jr.研究人员使用他的NIA支持失眠数据库的自然史 （R01AG041783）。被邀请的个人将有专业领域以外的PI，因此将作为一个 PI有机会教和学。将在该奖项的第三年举行一次会议， 合作者将作为一个小组介绍和讨论他们的数据。意义：K24将支持Perlis博士 他努力为下一代提供以病人为导向的研究培训。

BEHAVIORAL SLEEP MEDICINE: TRAINING IN SLEEP & AGING ABSTRACT Goals: In this proposal, Dr. Michael Perlis requests support to: 1) stabilize and expand his mentoring of junior investigators in the domain of behavioral sleep medicine and in the biopsychosocial approach to the study of insomnia (etiology, pathophysiology, treatment outcome research, and treatment mechanisms of action studies); 2) engage a program of educational activities that will provide him and his mentees with a strong foundation for the assessment of aging as a moderating factor for insomnia research; and 3) establish a collaborative network with junior investigators to conduct hypothesis-driven research with his NIA supported project on the natural history of insomnia. Background: Dr. Perlis has been involved in patient-oriented research since his mid-20's. He has been the beneficiary of exceptional mentorship and has carried forward this tradition over the entirety of his career. His research on Insomnia Disorder extends from basic research to patient-oriented research. Qualifications: The candidate has extensive experience as a PI, Co-PI, or Co-I on multiple NIH awards and a successful track record in mentoring others via NIH K23 and R21 mechanisms. Environment: The University of Pennsylvania (Penn) is one of the premier centers for sleep and chronobiology research and clinical work. As such, it has much to offer both the PI and his trainees. Development Activities: The core activity for the mentor's professional development will be the implementation of a monthly seminar series focused on Sleep and Aging. Leading scientists will be invited to Penn to discuss their ideas with respect to the effects of aging on sleep need, sleep ability and sleep opportunity and how alterations within these domains confer increased risk for sleep disorders and adverse health outcomes. In addition, the mentor/PI will take one workshop or course per year focused on biopsychosocial perspectives on aging and one workshop pertaining to bioethics. Mentoring Program: As the Director of Penn's Behavioral Sleep Medicine program, Dr. Perlis has created a unique set of educational activities that attract a wide array of trainees including established professionals, junior investigators, post-doctoral fellows, graduate and medical students, post baccalaureates, and undergraduates. The plan for this K24 is to provide trainees with a set of educational activities that include professional development, focused training in behavioral sleep medicine, and an in-depth appreciation regarding the quantitative assessment of sleep continuity (e.g., sleep diary assessments, actigraphy, PSG, & QEEG). Research: The candidate proposes to create a collaborative network to conduct archival analysis with Jr. Investigators using his NIA supported natural history of insomnia databases (R01AG041783). The individuals invited will have specialty areas apart from the PI, and thus will serve as an opportunity for the PI to both teach and learn. A conference will be held in the 3rd year of the award at which the collaborators will present and discuss their data as a group. Significance: This K24 will support Dr. Perlis in his efforts to provide patient-oriented research training to the next generation.