Population Science and Cancer Control Program

人口科学和癌症控制（PS）计划旨在产生研究发现， 西蒙斯综合癌症中心（SCCC）北德克萨斯集水区的癌症负担和差异 地区及以外。PS计划的具体目标是：（1）识别和评估生物标志物，以评估癌症 风险，早期发现并预测进展，（2）在多个层面上识别与癌症相关的因素 预防和早期检测、诊断、治疗和生存护理的提供、过程和结果， 和（3）开发和测试干预措施，以改善循证癌症预防的实施， 控制服务，重点是服务不足的人群和安全网医疗保健系统。PS计划 强调从预防和早期发现到治疗和治疗的整个癌症连续体的研究， 生存，致力于将发现转化为跨疾病部位和跨三个目标的研究。 PS计划由Simon Craddock Lee，PhD，MPH和Amit Singal，MD，MS共同领导 有27名成员，在UT西南医学中心（UTSW）的七个部门和两个 在公共卫生的UT学校的达拉斯地区校区的部门。招募的调查员和 自2014年以来被任命为教师包括生物统计学，数据科学，流行病学，地理空间 科学、卫生服务研究、社会心理学和烟草控制。PS计划的资金基础是 呈上升趋势，目前的总资金基础为590万美元，预计由于关键的新项目， 招聘到该计划。在总金额中，98%（580万美元）是同行评审的，其中310万美元来自NCI。的 与2014年的数据相比，PS计划的总研究资金基础增长了9%， 已进行调整，以符合修订后的癌症中心支持补助金指南。不包括在2019年 研究基础是基础设施和核心的大量资金，支持该计划的两个 以人口为基础的研究，以优化筛选过程（PROSPR）合作协议。的 复杂的数据收集基础设施对于支持与PROSPR相关的项目至关重要， 其合作努力的主旨是增加我们对医疗保健系统、提供者和个人的了解， 影响癌症筛查质量的水平因素和SCCC对服务不足人群的关注。的PS 程序已成为善于进行假设驱动的研究，往往通过大规模的务实试验 设计，以推进癌症预防和控制的护理服务。自2014年以来，PS计划成员 撰写了498份同行评审出版物：31%为方案内工作，34%为方案间工作 合作，49%是机构间的。

The Population Science and Cancer Control (PS) Program seeks to generate research discoveries addressing cancer burden and disparities in the Simmons Comprehensive Cancer Center’s (SCCC) North Texas catchment area and beyond. The PS Program specific aims are to: (1) identify and evaluate biomarkers to assess cancer risk, detect it early, and predict progression, (2) identify factors, at multiple levels, that are associated with cancer prevention and early detection, diagnosis, treatment, and survivorship care delivery, processes, and outcomes, and (3) develop and test interventions to improve implementation of evidence-based cancer prevention and control services, with a focus on underserved populations and safety-net healthcare systems. The PS Program emphasizes research across the cancer continuum from prevention and early detection, through treatment and survivorship, working to translate discoveries to inform research across disease sites and across the three aims. The PS Program is co-led by Simon Craddock Lee, PhD, MPH, and Amit Singal, MD, MS. The PS Program has 27 members, across seven departments in the UT Southwestern Medical Center (UTSW) and two departments in the Dallas Regional Campus of the UT School of Public Health. Investigators recruited and appointed to the faculty since 2014 include experts in biostatistics, data science, epidemiology, geospatial science, health services research, social psychology, and tobacco control. The PS Program’s funding base is on an upward trend, with a current total funding base of $5.9M, which is predicted to accelerate due to key new recruitments into the program. Of the total amount, 98% ($5.8M) is peer-reviewed, with $3.1M from the NCI. The PS Program’s total research funding base represents an increase of 9% compared with 2014 data, which have been adjusted to conform with the revised Cancer Center Support Grant guidelines. Not included in the 2019 research base is the significant amount of funding for the infrastructure and cores that support the program’s two Population-based Research to Optimize the Screening Process (PROSPR) cooperative agreements. The sophisticated data collection infrastructure is essential in supporting the projects associated with PROSPR and the thrust of its cooperative effort to increase our understanding of healthcare system, provider, and individual- level factors that affect the quality of cancer screening and SCCC’s focus on underserved populations. The PS Program has become adept at conducting hypothesis-driven research, often through large pragmatic trial designs, to advance care delivery in cancer prevention and control. Since 2014, PS Program members have authored 498 peer-reviewed publications: 31% represent intraprogrammatic work, 34% are interprogrammatic collaborations, and 49% are interinstitutional.