Cancer Center Support (Core) Grant

总体：摘要/摘要 在过去的四十年里，麻省理工学院一直致力于癌症研究，首先是以麻省理工学院中心的形式 自2007年以来，该研究所被称为麻省理工学院的科赫综合癌症研究所。 这项工作一直得到国家癌症中心支持赠款（CCSG）的支持。 癌症研究所（NCI），提供指定为麻省理工学院的NCI指定癌症中心。通过提供 为科赫研究所的核心设施和其他组织部分提供基础设施支持， 该CCSG是麻省理工学院癌症研究的重要资源。 从1974年CCR成立到过渡到科赫研究所并延续至今， NCI癌症中心的命名对麻省理工学院的管理产生了很大的影响， 在这整个过程中的机构支持。科赫研究所大楼的投资建设 2010年年底开业的新公司是这种支持的最新迹象。这座建筑聚集了27位癌症科学家 和癌症导向的工程师，形成一个高度跨学科和协作的研究环境。的 这座大楼也是麻省理工学院校园内癌症研究的中心， 中心的实验室位于附近的其他研究大楼。56名中心成员来自 麻省理工学院科学学院或工程学院的八个学术部门。超越发现 研究和技术开发正在追求由该中心的成员，重点是 以与临床中心和行业合作伙伴合作的形式进行转化研究。 科赫研究所的研究分为三个项目。每一个项目都取得了重大的成就。 在当前的补助金期间预付款。项目1：癌症遗传和细胞项目由Dr. 菲利普夏普，J克里斯托弗爱，和埃利泽卡洛。项目2：癌症生物学和免疫学由 Drs.理查德·海因斯，戴恩·维特鲁普，史蒂芬妮·斯普林格。程序3：系统和工程方法 由Michael Yaffe，Scott Manalis和Angela Koehler博士共同领导。这些程序的功能是 鼓励会员开展新的研究活动，并促进计划内和计划间的 合作。该中心的56名成员总共发表了1006篇与癌症有关的文章， 过去的补助期。其中，近18%涉及多个成员。该中心有一个与癌症有关的 资助基础为58，596，507美元TDC（见数据表2A/2B）。

Overall: Summary/Abstract Over the past four decades, MIT has had a focused effort in cancer research, first in the form of the MIT Center for Cancer Research (CCR) and, since 2007, as the Koch Institute for Integrative Cancer Research at MIT. This effort has been continuously supported by a Cancer Center Support Grant (CCSG) from the National Cancer Institute (NCI), providing the designation as an NCI-designated Cancer Center at MIT. By supplying infrastructural support for Core Facilities and other organizational components of the Koch Institute as well as funds for faculty recruitment and pilot projects, this CCSG is a critical resource for cancer research at MIT. From the establishment of the CCR in 1974 to the transition to the Koch Institute and continuing to the present, the NCI Cancer Center designation has had a strong influence on the MIT administration, leading to significant institutional support over this entire period. The investment in construction of the Koch Institute building (opened in late 2010) is a recent indication of this support. The building brings together 27 cancer scientists and cancer-oriented engineers to form a highly inter-disciplinary and collaborative research environment. The building is also the hub of cancer research on the MIT campus, with a nearly equal number of Members of the Center having their laboratories in other research buildings nearby. The 56 Center Members are drawn from eight academic departments at the School of Science or School of Engineering at MIT. Beyond the discovery research and technology development being pursued by the Members of this Center, significant emphasis is placed on translational research in the form of collaborations with clinical centers and industry partners. Research in the Koch Institute is organized into three Programs. Each of these Programs has made significant advances over the current grant period. Program 1: Genetic & Cellular Programs in Cancer is co-led by Drs. Phillip Sharp, J Christopher Love, and Eliezer Calo. Program 2: Cancer Biology & Immunology is co-led by Drs. Richard Hynes, Dane Wittrup, and Stefani Spranger. Program 3: Systems and Engineering Approaches to Cancer is co-led by Drs. Michael Yaffe, Scott Manalis, and Angela Koehler. These Programs function to stimulate new research initiatives by their Members as well as to foster intra- and inter-programmatic collaborations. In aggregate the 56 Members of this Center have published 1006 cancer-related articles over the past grant period. Of those, nearly 18% have involved multiple Members. The Center has a cancer-related funding base of $58,596,507 TDC (see Data Tables 2A/2B).